The first trial was made on the 16th of October, 1846. Morton gave the ether to a patient in the Massachusetts General Hospital, and Dr. Warren removed a tumour from his neck. The result was not complete success; the patient hardly felt the pain of cutting, but he was aware that the operation was being performed. On the next day, in a severer operation by Dr. Hayward, the success was perfect; the patient felt nothing, and in long insensibility there was no appearance of danger to life. The discovery might already be deemed complete, for the trials of the next following days had the same success, and thence onwards the use of the ether extended over constantly widening fields. A coarse but feeble opposition was raised by some American dentists; a few surgeons were over-cautious in their warnings against suspected dangers; a few maintained that pain was very useful, necessary perhaps to sound healing; some were hindered by their dislike of the patent which Morton and Jackson took out; but as fast as the news could be carried from one continent to another, and from town to town, so fast did the use of ether spread. It might almost be said that in every place, at least in Europe, where the discovery was promoted more quickly than in America, the month might be named before which all operative surgery was agonizing, and after which it was painless. But there were other great pains yet to be prevented, the pains of childbirth. For escape from these the honour and deep gratitude are due to Sir James Simpson. No energy, or knowledge, or power of language less than his could have overcome the fears that the insensibility, which was proved to be harmless in surgical operations and their consequences, should be often fatal or very mischievous in parturition. And to these fears were added a crowd of pious protests (raised, for the most part, by men) against so gross an interference as this seemed with the ordained course of human nature. Simpson, with equal force of words and work, beat all down; and by his adoption of chloroform as a substitute for ether promoted the whole use of anæsthetics.