Encouraged by his success Wells went to Boston, wishing to enlarge the reputation of his discovery and to have an opportunity of giving the gas to some one undergoing a surgical operation. Dr. J. C. Warren, the senior Surgeon of the Massachusetts General Hospital, to whom he applied for this purpose, asked him to show first its effects on some one from whom he would draw a tooth. He undertook to do this in the theatre of the medical college before a large class of students, to whom he had, on a previous day, explained his plan. Unluckily, the bag of gas from which the patient was inhaling was taken away too soon; he cried out when his tooth was drawn; the students hissed and hooted; and the discovery was denounced as an imposture. Wells left Boston disappointed and disheartened; he fell ill, and was for many months unable to practice his profession. Soon afterwards he gave up dentistry, and neglected the use and study of the nitrous oxide, till he was recalled to it by a discovery even more important than his own. The thread of the history of nitrous oxide may be broken here. The inhalation of sulphuric ether was often, even in the eighteenth century, used for the relief of spasmodic asthma, phthisis, and some other diseases of the chest. Dr. Beddoes and others thus wrote of it: but its utility was not great, and there is no evidence that this use of it had any influence on the discovery of its higher value, unless it were, very indirectly, in its having led to its being found useful for soothing the irritation produced by inhaling chlorine. Much more was due to its being used, like nitrous oxide, for the fun of the excitement which its diluted vapor would produce in those who freely inhaled it. The beginning of its use for this purpose is not clear. In the _Journal of Science and the Arts_, published in 1818 at the Royal Institution, there is a short anonymous statement among the "Miscellanea," in which it is said, "When the vapor of ether mixed with common air is inhaled, it produces effects very similar to those occasioned by nitrous oxide." The method of inhaling and its effects are described, and then "it is necessary to use caution in making experiments of this kind. By the imprudent inspiration of ether a gentleman was thrown into a very lethargic state, which continued with occasional periods of intermission for more than thirty hours, and a great depression of spirits; for many days the pulse was so much lowered that considerable fears were entertained for his life."