The fright at having, it was supposed, so nearly killed the boy, put an end to ether-frolics in that neighbourhood; but in 1842 Wilhite had become a pupil of Dr. Crauford Long, practising at that time at Jefferson (Jackson County, Georgia). Here he and Dr. Long and three fellow-pupils often amused themselves with the ether-inhalation, and Dr. Long observed that when he became furiously excited, as he often did, he was unconscious of the blows which he, by chance, received as he rushed or tumbled about. He observed the same in his pupils; and thinking over this, and emboldened by what Mr. Wilhite told him of the negro boy recovering after an hour's insensibility, he determined to try whether the ether-inhalation would make any one insensible of the pain of an operation. So, in March, 1842, nearly three years before Wells's observations with the nitrous oxide, he induced Mr. Venable, who had been very fond of inhaling ether, to inhale it till he was quite insensible. Then he dissected a tumour from his neck; no pain was felt, and no harm followed. Three months later, he similarly removed another tumour from him; and again, in 1842 and 1845, he operated on three other patients, and none felt pain. His operations were known and talked of in his neighbourhood; but the neighbourhood was only that of an obscure little town; and he did not publish any of his observations. The record of his first operation was only entered in his ledger: "James Venable, 1842. Ether and excising tumour, $2.00." He waited to test the ether more thoroughly in some greater operation than those in which he had yet tried it; and then he would have published his account of it. While he was waiting, others began to stir more actively in busier places, where his work was quite unknown, not even heard of. Among those with whom, in his unlucky visit to Boston, Wells talked of his use of the nitrous oxide, and of the great discovery which he believed that he had made, were Dr. Morton and Dr. Charles Jackson, men widely different in character and pursuit, but inseparable in the next chapter of the history of anæsthetics.