THAT I may dispatch as much as possible in a few Words, it now lies before me to describe the common Method of its Eruption; in the Beginning is a sharp pricking Pain upon the Part affected, which in a little Time grows very hot, and then lifts up the Cuticle into a Blister, containing a thin _Ichor_; but after the Vesicle is by rubbing or any other Accident broke, and the contained Fluid by Heat dissipated, its caustick Quality leaves an _Eschar_ behind, which crusts over, in some sooner, and in others later; its Extension is various, sometimes more broad, and at others more contracted; nor is its Colour more certain; in the greatest Degree of Inflammation it is extreamly red, but for the most Part it is dusky, very often livid, and sometimes, from the peculiar Virulence of the pestilential Poison, even quite black. BUT as there is a Quality in the pestilential Venom not yielding even to an actual Cautery, and from which in the Production of Carbuncles _Eschars_ are generated, I take it to be of Consequence to know how such a sharp, burning, and caustick Humour comes to be bred in an humane Body; and by what Contrivance of Nature it comes to be thus separated and thrown out? AND in an Affair of this Difficulty, I expect to be candidly set right by any one who thinks me mistaken. The whole Tribe of Diseases an humane Constitution is subject to, does undeniably prove that our Bodies are capable of producing many venomous Taints, even equal to any Thing in the Air or the Earth; nay, the Histories of Physick give many Instances of poisonous Insects and Animals bred within us; and no one can be ignorant, that besides the Disposition of corrupted Humours within us to generate such Creatures, that their _Semina_ are often brought to us from without: And this is very manifest in a _private_ Pestilence, (if that Term may be allowed me) where, without any Help from external Contagion, not only a poisonous _Seminium_ may be generated, but Carbuncles also may break out; that is, from the peculiar caustick Quality of saline Particles in the Body. WHEREFORE if this can be done in a _private_ Pestilence, what may we not expect from a Pestilence that is the Consequence of an Epidemick Cause; for the additional Assistance of a more powerful saline Principle from without, cannot but greatly actuate the animal Juices, and induce a compound Malignity abundantly sufficient for the Production of pestilential Carbuncles.