THE more aggravated therefore the saline Qualities of this foreign saline Principles shall be, and in Proportion to the Quantities of it insinuated into the animal Fluids, the Carbuncles will break out more or fewer, sooner or later; although as long as the pestilential Poison flows in Company with other Fluids within the Vessels, it seems more mild, because then diluted, than when separated and thrown upon the Skin by the natural Excretory Powers. And this Expulsion of it seems much to be assisted by the common Tendency of serous Particles towards the Surface, and the Congress of nitro-aereal Particles therewith; but nothing however is more manifest than that when the pestilential Poison hath got to the Surface, it exercises its Virulence upon all the Parts it touches, and leaves cruel Marks of its Triumph behind; the same as which likewise obtains not only from an epidemick Pestilence, but upon drinking any poisonous Draughts. BUT it concerns us here to remove one Mistake; For it is laid down by _Diemebrooeck_, in Opposition to the common Opinion, that a Carbuncle is nothing else but an actual Gangrene; for if any Credit may be given to our Experience, which we look upon to be as well founded as that of this great Man, I do not remember any Carbuncles (unless where there hath some manifest Error been committed in external Applications, or the Virulence of the Pestilence hath been greater than ordinary) to have tended more to a Sphacelation, than any other Consequences of the pestilential Poison. And were there not innumerable Testimonies to the Truth of this, many Arguments might be alledged in its Vindication; for while there is a free Influx of vital Spirits, and other natural Fluids, into the Part affected; while the native Heat is preserved from Suffocation, and Putrefaction is prevented, what Person can imagine there to be any particular Disposition to Mortification in a single Carbuncle? And the more especially when the Spirits are so far from being intercepted by the Carbuncle’s Eruption, that they flow more plentifully to the Part; when the native Heat is so far from being suffocated; that by its Assistance a salutary Separation is made; and lastly, when the Part affected is so far from Putrefaction, and rendered more humid than before, that these saline Particles of an escharotick Quality, rather prevent Mortification, and by drying the Part make it rather more able to resist such a Change: And according to the best of my Remembrance, I never did meet with a Carbuncle that mortified, unless from the Mismanagement or Carelesness of Surgeons, or when the highest Degree of Virulence in the pestilential Poison had not occasioned an immediate Sphacelation.