That disease [the hot and violent ague] had not long left me, til (within three weekes after I had gotten a little strength) I began to be distempered with other greevous sicknesses, which successively and severally assailed me: for besides a relapse into the former disease, which with much more violence held me more than a moneth, and brought me to great weakenesse, the flux surprised me, and kept me many daies: then the crampe assaulted my weak body, with strong paines; and afterwards the gout (with which I had heeretofore beene sometime troubled) afflicted mee in such sort, that making my body through weakenesse unable to stirre, or to use any maner of exercies, drew upon me the disease called the scurvy; which though in others it be a sicknesse of slothfulnesse, yet was in me an effect of weaknesse, which never left me, till I was upon the point to leave the world. When a person of strong constitution, living under the best conditions the colony could provide, and accompanied by a well-trained physician, found himself thus incapacitated, it is no wonder that the rank and file of the colony failed to pursue energetically by hard work and exemplary conduct their own best interests. The firmness of De la Warr, who was much more indulgent of his own than of others' disorders, brought additional stability to the colony, but the attack of scurvy, which current opinion believed could be relieved only by the citrous fruits of the West Indies, caused him, accompanied by Dr. Bohun, to set sail from Virginia in the spring of 1611 for the same island of Nevis praised so highly for its baths by the first settlers of 1607. Disease had robbed the colony of another outstanding leader during a period when strong leadership on the scene was imperative. Although the colony had experienced its worst years of hardship before De la Warr departed and the worst years in the New World had been caused by famine and disease, sickness and starvation were still to have a noteworthy effect. Disease no longer threatened the colony's life, but it shaped its history. In 1624 the charter of the Company was annulled and, in explaining this major development, account must be taken of the cumulative effects of sickness and hunger upon the Company's fortunes; the first summer's seasoning and the Starving Time, for example, had long-term economic repercussions as well as short-term results in human suffering.