The Company had been in financial difficulties for some years and by 1624 the treasury was empty and the indebtedness heavy. If the mortality rate had not been so high and the level of energy of the colonists so reduced, the Company might have prospered. For example, local trade with the Indians necessitated small ships for the effective transportation of cargo, but several attempts by the Company to send to America boatwrights to construct such ships failed because of the deaths of the boatwrights. The Company had hoped in 1620 to better its financial condition by developing an iron industry in the colony, but this project suffered from the effects of disease, too, as the chief men for the iron works died during the ocean voyage. The remainder of the officers and men sent to establish the works died in Virginia either from disease or at the hands of the Indians. The high cost to the Company of the labor and services lost because of the early deaths of persons still indentured for a period of years cannot be estimated. Nor can the number of goals set by the colonists and the Company but never fulfilled because of sickness be tabulated. As late as 1623 a colonist wrote that "these slow supplies, which hardly rebuild every year the decays of the former, retain us only in a languishing state and curb us from the carrying of enterprise of moment." In suggesting the part that famine and disease played in the annulment of the Company's charter, the effects of one more period of intense suffering must also be considered. In March, 1622, a bloody Indian massacre occurred in which more than 350 white men, women, and children died. Not only did the massacre cause a subsequent period of disease, famine, and death among the survivors, but the heavy casualties inflicted directly by the Indians can be explained, partially, by the weakened condition and depleted ranks of the colonists before the massacre. So tenuous was the colony's ability to maintain an adequate and healthful living standard, that the destructive and disrupting impact of the massacre brought a period of severe famine and sickness. After the raid the surviving colonists had to abandon many of the outlying plantations with their arable fields, livestock, and supplies. And having had the routine of life interrupted, the settlers--their numbers unfortunately increased by a large supply of new immigrants, sent by ambitious planners in England--came to the winter of 1622-23 poorly provisioned.