In the meanwhile what is to be said as to the progress of pathological research? The earliest contribution to psychiatry from that point of view was made by Morgagni in 1761, his opinions being based on the autopsy reports in some thirteen cases. Greding in 1790 published the results of autopsies in a series of thirty-seven cases. The findings at that time included variations in the thickness of the skull, adhesions and thickenings of the dura, changes in the consistency of the cerebrum and cerebellum, effusions into the ventricles and various gross defects. The early writers attached a great deal of importance to the pineal gland changes. These pathological conditions were so generally reported, that Portal in the eighteenth century went so far as to say that "Morbid alteration in the brain or spinal marrow has been so constantly observed, that I should greatly prefer to doubt the sufficiency of my senses, if I should not at any time discover any morbid change in the brain, than to believe that mental disease could exist without any physical disorder in this viscus, or in one or other of its appurtenances." Pinel spoke very discouragingly, however, of the results and Esquirol finally reached the conclusion that nothing really important had been accomplished after all. In his Charenton reports (1835) he expressed himself on this subject as follows:—"However important may have been the researches of anatomists made during our days into diseases which affect the mind, we may venture to repeat that pathological anatomy is yet silent as to the seat of madness, and that it has not yet demonstrated what is the precise alteration in the encephalon which gives rise to this disease. What shall we, then, think of the rash pretensions of those who assume that they can fix upon the diseased portion of the brain, judging merely from the character of the disease?" In 1836 Guislain summarized the various lesions found in insanity at autopsy under nine headings—congestion of the brain or meninges or both, serous congestion of the same, cerebral softening, adhesions of the membranes to each other or to the brain, cerebral induration, cerebral hypertrophy, and abnormalities of the brain or skull. The appointment of a pathologist at the Utica State Hospital in 1868 as a result of the remarkable interest taken in this subject by Dr. John P. Gray must be looked upon as one of the important events in the history of American psychiatry. The later developments of the nineteenth century included studies of general paresis, cerebral syphilis, arteriosclerosis, senility, epilepsy, mental deficiency, pellagra and various other somatic conditions. It may fairly be said, at least, that pathology has kept fully abreast of the progress made by clinical psychiatry during the nineteenth century.