From San Juan, and later (1610) from Santa Fe, Oñate, his men, and his colonists brought New Mexico under the Spanish yoke. In co-operation with the Franciscan Order, which had been assigned the task of converting the Indian, Oñate supervised the building of missions and mission churches at many of the pueblos of New Mexico. At the same time, Spanish towns developed, the most important being the new capital at Santa Fe. By 1628, New Mexico was solidly in the hands of her new masters. The period from 1628 to 1680 was one of internal conflict and isolation for New Mexico. It lay far out on the frontier, alone and distant from its source of supplies. It lacked many of the items necessary for frontier life, particularly hardware and clothing. Its population was small, and in constant fear of Indian uprising, and its officials were too weak to act with vigor. Finally, there was a lack of genuine interest on the part of the central authorities. All these problems led to internal conflicts between soldier and colonist; between colonist and Indian; between colonist and official; and, perhaps most bitter of all, between church and state. This latter conflict would erupt time after time, openly, and with bitterness and denunciation from both sides. Governors were excommunicated as heretics; Franciscans were accused of all sorts of crimes and improper behavior. This, plus the other conflicts, gave rise to growing disrespect by the Indians for their European conquerors. The superiority of Christianity was questioned by the Indians as they watched the attacks and counterattacks made by priest and governor. The whole system of Spanish rule seemed a mockery. In 1680, the Indians decided their way was best after all and rose in rebellion. Led by Po-pé from Taos, the various pueblos banded together in a mighty effort to remove the Spanish from traditional Indian lands. For the first time the pueblos came together, united by a single purpose. There were two exceptions; Isleta, just south of Albuquerque, and the Piro villages farther south (Socorro) remained loyal to the Spanish. Up and down the Rio Grande Valley, the Spaniards fell before the pent-up anger of the Indians. Survivors gathered at Santa Fe, but their water supply was cut, and they were forced to retreat south. At Isleta and later at the Piro villages, they received aid before continuing south to El Paso del Norte. With them went their Indian allies from Isleta and Socorro. It was a total defeat for the Spanish, and the Indian again was master of New Mexico.