Miss W., 42 years old, passed her childhood in the West Indies, and brought from there a peculiar skin disease. When I saw her for the first time her features looked old for her age, skin gray and sallow, hair gray, rough, full of dandruff, and moisture oozing from the ears and forehead. The scalp feels hard and thickened. The cervical glands are indurated all around the neck. On the left chest an herpetic eruption of the size of a dollar, and on the mamma a hard tumor of the size of a fist. For a year past this tumor began to be painful and sensitive to pressure, and my advice was sought for relief of all her ailments, especially as her hands were also in a fearful state, where the eruption looked as if she had the itch. The nails were discolored, knobby, easily bleeding and covered with a gluey eruption. She had to wear and to change gloves every day. For nine years she never entered society, as the exhalation from her body disgusted even herself, and was hardly bearable, though sponging the whole body and daily renewal of linen was strictly adhered to. In such an obstinate chronic psoric case treatment with small doses is at first necessary, and _Arsen. brom._, two drops twice daily, ordered, and her cold bath continued. After four weeks the dose was doubled, and after nine weeks the first glimmer of improvement could be seen. The tumor in the mamma was smaller and painless, and where before it was so sensitive as to be covered with oil-silk she could bear now the pressure of her clothing. After four months steady continuation of four drops twice daily, she was able to go without gloves. The scalp also was cleaner, less hard, and the ears more dry. But with the return of spring the eruption gained new vigor. The head and hands became covered with suppurating nodules and small exuding herpetic spots, which became confluent and itched terribly, a most classic picture of the herpes of the ancients. Though for years she had been accustomed to an aggravation in the spring, she never witnessed it in such severity. I now omitted the drug and ordered head and hands frequently washed with cold water. After eight days the storm calmed down, and it was remarkable to witness the steady decrease of the induration in the cervical glands and mamma. After four weeks the old treatment was renewed. During the summer months she took regularly her four drops twice daily, and in the beginning of autumn the dose was reduced to two drops, and so continued during the whole winter. The following spring crisis was the mildest one she ever experienced. During the summer she took her four drops, during fall and winter two drops. The third spring aggravation came with full severity, but lasted only three days, when desquamation followed. Another year of the same treatment and the fourth spring eruption showed itself slightly only in small papules behind the ears and between the fingers, and were hardly worth noticing.