Footnote 35: Lorand: Loc. cit. Osteomalacia, which is associated with an enormous elimination of calcium carbonate is, as we at present consider, due to an exaggerated ovarian activity (Fehling), and can be favorably influenced by castration or, by what would be more reasonable, thyroid treatment. No less powerful than that of the thyroid is the influence of the pituitary body upon the skeleton, especially upon the hands, feet, and skull. And if we wish to demonstrate how much the ductless glands influence the looks of a person, it is sufficient to point out the great changes that take place in the face of a patient with acromegaly. This disease makes such persons look very much as “Punch” is depicted. The skin and complexion of persons suffering from changes in the ductless glands are also very different from normal. Thus Addison’s disease, due, as well known, to a degeneration of the adrenals, makes a white man look more or less like an Indian, and there is a pigmented skin also in persons affected by the partial form of that rare disease. We can also easily show that changes in the thyroid are followed by changes in the condition of the skin. Thus, with thyroid degenerations, as in myxœdema, the skin is pale with a yellowish tinge. In Graves’s disease pigmentation of the skin can often be observed, and not rarely cutaneous eruptions. In affections of the sexual organs in woman similar conditions of the skin can occur. Such persons often present wrinkles at a very early age, and certainly look older than their years. Infants suffering from congenital degeneration of the thyroid gland often look withered and present a face as wrinkled as a sexagenarian. We see this also in congenital syphilis (atrophy of the thyroid). The hair also very often shows alterations in diseases of the thyroid, or ovaries. Thus, in myxœdema there is an atrophy of the follicles of the hair, which falls out, even in the case of the eye-brows. It is particularly interesting that, by thyroid medication, a new growth of hair has been observed in places where it had fallen out years previously, as we have observed, with other authors, in several cases after thyroid medication. And, very strange to say, this newly-grown hair was quite dark while the hair that had previously been in its place was gray in color. It has been authentically stated by several authorities that old persons of sixty or seventy have acquired black hair under thyroid treatment. On the other hand, in much younger persons, perhaps under thirty, who are suffering from complete or partial degeneration of the thyroid gland, the hair very often turns gray; so much so that Hertoghe considers this to be one of the typical symptoms of such a condition.