I have rarely seen a decided fit of hysteria from the effects of chloroform, but in the case of a young married lady, to whom I gave this agent to prevent the pain of an operation on the rectum, a somewhat violent paroxysm of hysteria came on directly after the inhalation was commenced. The surgeon would not permit me to continue the chloroform, and expressed his intention of operating without it. After waiting for about half an hour, however, for the hysteria to subside, and finding that it continued the same as at first, the inhalation was resumed. The patient was soon rendered insensible, and lay perfectly still whilst the operation was performed. There was a little hysteria as the effects of the chloroform subsided, but not so severe as before. I have several times seen hysterical symptoms in the male, either during the administration of chloroform, or whilst the patient was recovering from its effects. But in all these cases, the patients informed me afterwards that they were subject to hysterics when under the influence of mental emotion. In some persons who are subject to hysteria, the breathing becomes excessively deep and rapid whilst inhaling chloroform. This usually occurs just as the patient is becoming unconscious, but in a few cases even earlier, and the patient is aware of the impulse to breathe in this manner. After this kind of hysterical breathing has lasted a minute, the patient generally rests nearly a minute without breathing at all, after which the respiration generally becomes nearly natural. I give the chloroform very sparingly during this violent breathing, or else withdraw it altogether for a minute or two. I do not consider that the hysterical diathesis forms any objection to the use of chloroform in operations, as the patients would be generally quite as liable to suffer an attack of hysteria from the pain, if chloroform were not used. _Epilepsy._ Chloroform occasionally brings on a fit of epilepsy in persons who are subject to this disease. It was stated in one of the foreign medical journals, in 1848, that this agent was so certain to cause a fit in epileptic persons, that it might be used to detect impostors pretending to be subject to this disease; but if this assertion has been acted on, it must have led to great injustice, for I have many times administered chloroform to the extent of causing complete insensibility in epileptic patients who required to undergo operations, without its inducing the least approach to a fit.