_Experiment 6._ A guineapig was placed in the jar holding 3,000 cubic inches, and 37·5 grains of chloroform were introduced in the same manner as in the former experiments, being a grain and a quarter to each 100 cubic inches of air. The chloroform took three or four minutes to evaporate and diffuse itself in the jar; and by the end of this time the guineapig, which had been excited and running about, began to stagger, and in two minutes longer it was unable to walk, but endeavoured to keep its balance when the jar was inclined. At the end of a quarter of an hour it was lying still, but moved its limbs when it was rolled over by inclining the jar; but it made no voluntary effort. It was taken out when thirty-three minutes had elapsed. It moved its limbs as it was removed, though apparently not in a voluntary manner. Its limbs were not relaxed. It was quite insensible to pricking. It recovered in about ten minutes. The temperature in the axilla before it was put into the jar was 100° Fah., and immediately after its removal 96°. _Experiment 7._ A guineapig was placed in the same jar, and forty-five grains of chloroform were introduced, being a grain and a half to each 100 cubic inches of air. In four minutes after the chloroform had evaporated, the guineapig was unable to walk. In half a minute more it seemed asleep, but there was a tremulous motion of the hind legs, which continued till ten minutes had elapsed. Afterwards it lay still, but winked now and then spontaneously. When rolled over by moving the jar, it made no voluntary effort. It was taken out twenty minutes after the chloroform had evaporated. It winked spontaneously, and also when the eyes were touched. It did not flinch when the ear was pricked, but flinched when the paw was pricked. The temperature in the axilla before the experiment was 100°, and immediately afterwards it was 96°. The guineapig recovered from the effects of the chloroform in ten minutes. _Experiment 8._ A guineapig was put into the same jar, and 52·5 grains of chloroform were introduced, being a grain and three-quarters to each 100 cubic inches of air. The chloroform evaporated in the course of four minutes, at the end of which time the guineapig was altered in its manner, as if partially inebriated. In two minutes more it was becoming drowsy. A little while afterwards it was lying down. Six minutes after the evaporation of the chloroform was complete, the guineapig made no effort when turned over by inclining the jar, but only moved its feet, as it were automatically. At the end of nine minutes, it was lying quietly and breathing naturally. When fifteen minutes had elapsed it was in the same condition, and was removed from the jar. It cried and flinched on the foot being pricked. The temperature in the axilla was 97°. In five minutes after its removal it was fast recovering, and in ten minutes was quite recovered.