On chloroform and other anæsthetics: their action and administrationSnow, John
History
On chloroform and other anæsthetics: their action and administration
Snow, John
Anesthetics; Chloroform; Snow, John, 1813-1858
_Experiment 13._ A guineapig was put into a jar holding 3,000 cubic
inches, and 67·5 grains of chloroform were introduced on blotting paper
suspended within the jar, being 2¼ grains to each 100 cubic inches. In
four minutes, the chloroform had all evaporated, and the guineapig was
becoming affected. In two minutes more, it was quite insensible. Eight
minutes after the chloroform had evaporated, it was lying still,
breathing forty times in the minute. During the next three or four
minutes, it moved one or other of its legs occasionally. At the end of
seventeen minutes, it was lying still, and the breathing was twenty-six
in the minute. It was taken out at the end of twenty minutes quite
insensible; in three or four minutes it began to try to walk, and in ten
minutes, was quite recovered.
_Experiment 14._ Two white mice, one being full grown, and the other
about three-quarters grown, were placed in the jar holding 1,600 cubic
inches, and forty grains of chloroform were introduced on blotting
paper, being two grains and a half to each hundred cubic inches. In two
minutes, the chloroform had evaporated, and the mice were much excited.
In another minute, they were unsteady in walking; and in a minute more,
the old mouse was lying insensible, and breathing deeply and
laboriously. In four minutes more, _i. e._, six minutes after the
chloroform had evaporated, the young mouse was insensible also, but was
moving one of its hind legs. In other four minutes, the young mouse was
breathing by slow gasps, whilst the old one continued to breathe deeply
as before. Three minutes later, i. e., thirteen minutes after the
chloroform had evaporated, the old mouse had begun to gasp, and the
young one was gasping only at intervals. They were removed, and
recovered completely in ten minutes. The young one recovered most
quickly. Their temperature, on being removed, was about 90°.
_Experiment 15._ A cat was put into the jar holding 3,000 cubic inches,
and 82·5 grains of chloroform were introduced, being two grains and
three-quarters to each hundred cubic inches. In five minutes, it had
evaporated, and the cat began to stagger in its walk. In two minutes
more, it was unable to stand. Five minutes after the chloroform had
evaporated, the cat was breathing deeply, seventy-five times in the
minute. At eight minutes, it was breathing less deeply, one hundred and
seventeen times in the minute. Ten minutes after the chloroform had
evaporated, the cat was quite insensible, and breathing one hundred and
twenty-six times in the minute. It was now taken out. The temperature in
the axilla was 98°. In half an hour after its removal from the jar, it
had recovered its consciousness, but was still drowsy.
Public-domain text, read in full here on John Shaqi.
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