On Digestive Proteolysis: Being the Cartwright Lectures for 1894Chittenden, R. H. (Russell Henry)
Science
On Digestive Proteolysis: Being the Cartwright Lectures for 1894
Chittenden, R. H. (Russell Henry)
Digestion; Digestive enzymes; Enzymes
so operated upon, after recovery was complete, solid food, as meat,
was completely digested when taken in small quantities at a time. Raw
meat, however, was less completely utilized, the fæces showing portions
of undigested fibres. Still, it was apparent that intestinal digestion
alone was capable of accomplishing all that was necessary for the
complete nourishment of the animal, when it had once become accustomed
to the changed condition of its alimentary tract.
[147] Bunge’s Physiologische und Pathologische Chemie, p. 152.
[148] Ueber die Verdauung nach der Ausschaltung des Magens. Du
Bois-Reymond’s Archiv f. Physiol, 1883, p. 89.
[149] Une observation de chien sans estomac. Comptes Rendus hebd. de la
Société de Biologie, December 1, 1893.
These facts are cited not to belittle the importance of gastric
digestion in the nutrition of the body, but rather to emphasize the
probability that pepsin-proteolysis is simply a preliminary step in
digestion; that its function is not in the direction of a complete
peptonization of the proteid foods ingested, but that its action is
especially directed to the production of soluble products, proteoses,
which can be further digested in the small intestine, or perhaps
directly absorbed after they have passed through the pylorus, or even
from the stomach itself to a certain extent.
SOME PHYSIOLOGICAL PROPERTIES OF PROTEOSES AND PEPTONES.
It is very evident from what has been said that all forms of proteid
matter, _i.e._, all the members of the three main groups spoken
of in our classification of the proteids, excepting only nuclein,
reticulin, and the keratins, are capable of undergoing proteolysis with
pepsin-hydrochloric acid. Further, in every case the main products
of the transformation are proteoses; viz., albumoses, caseoses,
gelatoses, vitelloses, myosinoses, etc., according to the nature of
the proteid undergoing proteolysis; true peptones being formed in
less abundance. Corresponding to each of these groups are primary and
secondary proteoses, all possessed of many points in common, both
chemical and physiological, yet differing from each other in many minor
respects. These are the important products of gastric digestion, of
pepsin-proteolysis, and it may be well to consider for a moment some
of the physiological properties of the proteoses and of peptones as
well, in order that we may the better comprehend the general nature of
these substances with reference to their possible action in the economy.
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