On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
The influence of the nervous system on the secretion of intestinal
fluid is very clear. It was found by Moreau[15] that section of the
nerves to the intestine brought about a large secretion of fluid
into the intestine resembling closely that obtained by a Thiry-Vella
fistula. Budge[16] had previously noted that extirpation of the ganglia
of the coeliac plexus caused an increase of fluid in the intestine.
The results of Moreau, who carried out his experiments with isolated
loops, have been repeatedly confirmed, and some question has arisen
as to the nature of the fluid secreted, some authors regarding it as
a transudation, others as a true secretion. It has been compared by
some to the rice water stools of Asiatic cholera, and on account of the
analogy with the secretion which pours from the salivary gland after
section of the chorda tympani it has been called a paralytic secretion.
Landois[17] ascribes the secretion to the cutting of vasomotor nerves
which causes circulatory changes so marked that a transudation of
fluid occurs. In the leg, however, it has been shown that the normal
transudation and lymph formation are not increased by section of the
nerves. One would also expect to find oedema of the intestinal wall
if this were a process of transudation due to vascular changes. Such
oedema does not occur.
The nature of the fluid obtained by section of the nerves to the
intestine has been studied by many investigators. Moreau described it
as a light yellow clear fluid with a strongly alkaline reaction. Its
specific gravity is 1.008. It contains carbonates, chlorides, organic
materials and a little urea. According to Hanau,[18] the fluid contains
no digestive ferments, although in the dog he found that in the first
part of the secretion fibrin was digested to some extent and starch
converted into sugar. This he ascribed to the presence of pancreatic
juice. Mendel[19] has recently worked on this subject and finds also
that the pure paralytic secretion has no digestive action on fibrin,
but that there is a slight amylolytic action. Cane sugar and maltose
are inverted, while milk sugar is not.
The fact that the paralytic secretion resembles very closely the normal
secretion both physically and chemically seems to indicate that it is a
true secretion and not a transudation.
Public-domain text, read in full here on John Shaqi.
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