Bottazzi[20] has recently found that an extract of the small intestine injected into the blood causes not only an increase in the fluid secreted into the intestine, but also an increase in the peristaltic movements. This extract is an aqueous one, the nucleoproteids being precipitated by acetic acid. It thus contains the secretin of Bayliss and Starling and is capable of increasing also the pancreatic secretion. The fluid produced in the intestine was later analyzed by Bottazzi and Gabrieli[21] and proved to be quite similar to the normal intestinal secretion. It is of some interest to note that the intestinal secretion and the pancreatic secretion are simultaneously augmented by the intravenous injection of this extract. FOOTNOTES: [2] Journal of Physiology, Vol. XXIV, 1899, p. 99. [3] Johns Hopkins Hospital Reports, Vol. I, 1896. [4] _Loc. cit._ [5] Deutsch. Med. Wochenschr., XV, 1899. [6] Amer. Journ. Physiol., Vol. VI, 1902. [7] Pflüger’s Archiv, VI, 1872; VIII, 1874. [8] Johns Hopkins Hospital Reports, I, 1896. [9] Arch. f. exp. Path. u. Pharm., Bd. 23-24. [10] De Motu peristaltic. intest. Treviris, 1750. [11] Über das Hemmungsnervensystem f. d. peristal. Bewegungen d. Darmes, Berlin, 1857. [12] Sitzungsb. d. k. Akad. d. Wissensch. Wien, 1864, Bd. 1. [13] Untersuchung. z. Naturl. d. Mensch. u. d. Thiere; 1881; Bd. XIII. [14] Arch. f. d. gesammte Physiologie, Bd. LXI, 1895, S. 359. [15] Centralbl. d. Medicin. Wissensch., S. 209, 1868. [16] Verhandl. d. K. K. Leop. Carol. Akad. d. N., Bd. 19, 1860. [17] Lehrbuch der Physiologie, 10th Ed., p. 360. [18] Zeitsch. f. Biologie, Bd. 22, 1886, p. 195. [19] Arch. f. d. ges. Physiol., Bd. 63, 1896, p. 425. [20] Arch. di Fisiologia, 1904, I, 413. [21] Arch. internationales de Physiologie, 1905, Vol. III, II, p. 156. CHAPTER II. The Subcutaneous and Intravenous Injection of Saline Purgatives.