On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
Experiments have recently been made to test the effect of adding
calcium salts to barium chloride and feeding the two mixed with some
edible substance to mice. BaCl_{2} is a common poison to employ for
mice and rats. It was found that the mice eating food containing
barium carbonate alone died, while those eating the mixture of calcium
carbonate and barium carbonate in the food were unharmed.[56]
When loops of the intestine are entirely removed from the body and
placed in sodium chloride solution, active movements begin, as will
be described in detail in a later chapter. These movements continue
40 to 45 minutes or longer if the proper conditions of temperature,
etc., are preserved. If, however, CaCl_{2} be added to this solution
the movements are inhibited. Also loops placed in pure m/6 CaCl_{2}
solution lie perfectly quiet.
A peculiar action of calcium which will be described in detail later
on is shown in the following experiments: A loop of rabbit’s intestine
was removed from the body and placed in a solution of m/6 LiCl. After
moving rhythmically for about 15 seconds the loop came to rest. A
loop similarly placed in m/6 CaCl_{2} solution showed no movements.
In a mixture, however, of 50 c.c. m/6 LiCl + 5 c.c. m/6 CaCl_{2} the
initial movements seen in the pure LiCl solution were absent and the
loop remained quiet for 10-15 minutes. Then sudden sharp constrictions
appear in the loop, followed by violent contractions of the whole loop.
The loop twists and coils upon itself and continues to move in this
extremely active manner for 30-45 minutes or longer. The control loops
in pure LiCl and pure CaCl_{2} remain motionless during all this time.
A similar phenomenon occurs with a mixture of NaCl and CaCl_{2}. In
NaCl, however, the initial movements are much more conspicuous and may
continue for an hour. These are inhibited in the mixture of NaCl and
CaCl_{2}, and after 10-15 minutes movements of an entirely different
character appear, resembling those described for mixtures of LiCl and
CaCl_{2}. Sharp constrictions and violent twistings persist for 30 or
40 minutes.
These peculiar contractions do not occur in mixtures of LiCl and NaCl,
nor in mixtures of CaCl_{2} and MgCl_{2}.
In addition to their action on the intestine, calcium and magnesium
have a very definite action on other organs of the body, more
especially the kidney. It was found[57] that both calcium and magnesium
chlorides inhibit the flow of urine. This is shown in the following
tables taken from the paper referred to.
Rabbit--cannula placed in bladder. No urine flowed in the first or
second periods of 10 minutes before the NaCl solution was injected.
Time Salts other than m/6 NaCl Urine
NaCl injected injected in c.c. in c.c.
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