On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
10:10 10
10:15 10
10:20 5 0.5
10:40 10 0.8
11:00 10 0.5
11:20 5 1.0
11:40 10 2.8
12:00 10 6.0
12:00 5 c.c. m/6 CaCl_{2}
intravenously
12:05 5 c.c. 5m/6 CaCl_{2}
subcutaneously
12:20 5 0.2
12:40 10 1.8
1:00 10 0.8
1:00 5 c.c. m/6 sodium citrate
intravenously
1:20 10 2.2
1:40 5 3.6
In this case, although the flow of urine was considerably increased
by the injection of NaCl solution, and although the injection was
continued, the introduction of CaCl_{2} caused the flow to almost
cease. This action was quite constant and was obtained in a large
number of experiments. MgCl_{2} has a similar but less powerful effect.
The action of the CaCl_{2} is temporary and wears off after a little
time, as shown in the following table taken from the same paper.
It represents only the latter half of the experiment, the regular
injection of 2 c.c. NaCl solution per minute gradually increasing the
rate of flow as shown, until the quantity of fluid excreted almost
equals that injected.
Rabbit--cannula in bladder--injections intravenous.
Time Salts other than m/6 NaCl Urine
NaCl injected injected in c.c. in c.c.
9:25
11:40 150 64.5
11:45 10 6.6
11:50 10 5.6
11:55 10 6.2
12:00 10 7.4
12:05 10 9.5
12:05 5 c.c. m/6 CaCl_{2}
12:10 5 2.2
12:15 10 0.8
12:20 10 1.2
12:25 10 1.6
12:30 10 2.8
12:35 8 3.0
12:40 5 4.5
12:45 0 4.8
12:50 0 5.1
12:55 0 6.2
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