On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
The normal movements of the intestine have been described by many
observers, and in these descriptions there is a fair amount of
uniformity. Ludwig and his pupils, Bayliss and Starling, Magnus and
others have studied this subject with much care. In such a complicated
organ as the intestine there are many sources of error, and differences
of opinion may readily arise if an attempt is made to analyze too
closely the functions of the various tissues making up the intestine,
to decide for example whether the movements are of nervous origin or
muscular, or whether the secretion is dependent primarily on the blood
supply or on the nervous system. For our purpose it will be sufficient
to regard the intestine as an organ composed of certain muscular
layers, certain nervous plexuses and certain glands--and to discuss the
action of various influences not on these separate tissues, but on the
organ as a whole, holding in mind also the nervous and bloodvascular
connections of the organ.
If the abdominal cavity of a dog, cat, or rabbit be opened under the
surface of m/6 NaCl solution or Ringer’s solution at body temperature,
it will be found that the intestines are not entirely at rest.
According to local conditions, more or less active movements will be
seen. These were described by Ludwig and others as consisting of two
kinds of motion, namely, the _pendulum movements_, and _peristaltic
movements_.
The pendulum movements are rhythmical, and consist of a regular slight
swinging of the loops upon one another. Their frequency has been
measured by Bayliss and Starling.[2] According to these observers, each
contraction and relaxation lasts 5 to 6 seconds, so that the rhythm
consists of 10 to 12 beats per minute. The rhythm is however not always
regular, the contents of the loop and other local conditions exerting
an influence. The cause of these pendulum movements is not perfectly
clear. By many they have been ascribed to a rhythmical shortening of
the intestine, _i.e._, a rhythmical contraction and relaxation of the
longitudinal muscle coat. Mall[3] regards them as arising mainly in the
circular layer; while Bayliss and Starling state that they are due to
simultaneous contractions of the circular and longitudinal coats.
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