On the mechanism of the physiological action of the catharticsMacCallum, John Bruce
Science
On the mechanism of the physiological action of the cathartics
MacCallum, John Bruce
Laxatives -- Physiological effect
The peristaltic movements consist of more or less strong contractions
of the circular coat of the intestine, varying from a slight ring-like
contraction which passes rapidly down the gut to a violent constriction
of the intestine which obliterates the lumen of the gut and passes
very slowly from above downward. The slight contractions may travel,
according to Bayliss and Starling, as rapidly as 2-5 cm. per second,
while the more violent ones move not more than ¹⁄₁₀ cm. per second.
According to Nothnagel, Mall, and others, the formation of these
peristaltic waves is always due to a local stimulus, usually the
presence of a bolus of food. The intestine contracts immediately above
the point of stimulation and the mass of food is forced downward. The
wave of contraction follows close behind the bolus, while for some
distance above this point similar waves run downward until they reach
the mass of food. The gut is usually relaxed below the bolus, and
the general statement has been made that a stimulation at any point
causes a contraction above that point and an inhibition below it.
It is generally thought that Auerbach’s plexus is concerned in the
propagation of the peristaltic wave since the peristalsis takes place
also when the intestine is separated from the central nervous system,
and does not occur when nicotine or cocaine is given to paralyze the
intrinsic nerves of the intestine.
In addition to the pendulum and the peristaltic movements, there is a
third quite distinct motion to be observed in the intestine. The normal
peristaltic movements are very slow, while this third type, called by
Nothnagel “Rollbewegung,” consists of a rapid contraction which may
pass from one end of the intestine to the other in 1 to 2 minutes. The
function of this movement is thought to be the rapid elimination of
irritating substances from the intestine. It occurs irregularly and is
more common in slight pathological conditions of the gut.
Public-domain text, read in full here on John Shaqi.
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