The existence of Asiatic Cholera cannot be distinctly traced back further than the year 1769. Previous to that time the greater part of India was unknown to European medical men; and this is probably the reason why the history of cholera does not extend to a more remote period. It has been proved by various documents, quoted by Mr. Scot,[1] that cholera was prevalent at Madras in the year above mentioned, and that it carried off many thousands of persons in the peninsula of India from that time to 1790. From this period we have very little account of the disease till 1814, although, of course, it might exist in many parts of Asia without coming under the notice of Europeans. In June 1814, the cholera appeared with great severity in the 1st bat. 9th regt. N.I., on its march from Jaulnah to Trichinopoly; while another battalion, which accompanied it, did not suffer, although it had been exposed to exactly the same circumstances, with one exception. Mr. Cruikshanks, who attended the cases, made a report, which will be alluded to further on. [Sidenote: ON THE MODE OF COMMUNICATION OF CHOLERA.] In 1817, the cholera prevailed with unusual virulence at several places in the Delta of the Ganges; and, as it had not been previously seen by the medical men practising in that part of India, it was thought by them to be a new disease. At this time the cholera began to spread to an extent not before known; and, in the course of seven years, it reached, eastward, to China and the Philippine Islands; southward, to the Mauritius and Bourbon; and to the north-west, as far as Persia and Turkey. Its approach towards our own country, after it entered Europe, was watched with more intense anxiety than its progress in other directions. It would occupy a long time to give an account of the progress of cholera over different parts of the world, with the devastation it has caused in some places, whilst it has passed lightly over others, or left them untouched; and unless this account could be accompanied with a description of the physical condition of the places, and the habits of the people, which I am unable to give, it would be of little use. There are certain circumstances, however, connected with the progress of cholera, which may be stated in a general way. It travels along the great tracks of human intercourse, never going faster than people travel, and generally much more slowly. In extending to a fresh island or continent, it always appears first at a sea-port. It never attacks the crews of ships going from a country free from cholera, to one where the disease is prevailing, till they have entered a port, or had intercourse with the shore. Its exact progress from town to town cannot always be traced; but it has never appeared except where there has been ample opportunity for it to be conveyed by human intercourse.