_Post-mortem appearances._ The wound in the left leg opened directly into the brachial vein, which was filled with lymph and a thin pus for a very short distance, both above and below the external opening; immediately above this, the vein was healthy, nor was there any appearance of disease in any of the other veins of the limb, nor in the veins leading to the heart. The glands in the axilla were swollen. The lungs were found studded irregularly in different parts, with circumscribed spots of livid congestion: these existed both upon the surface and in the substance of the lungs; they were generally about the size of a filbert, but in some places they occupied a single lobule, and were accurately circumscribed by its outline. EXPERIMENT VII. On the 23rd of November, 1848, about an ounce of perfectly pure pus (previously warmed) was injected into the right jugular vein of an aged ass; the vein immediately became "corded", and the blood appeared to have coagulated in the vessel. The operation did not much excite the breathing; but the pulse, which naturally was 35 in the minute, rose to 60, and subsequently fell to 55. _24th._ The animal dejected; appetite indifferent. The vein can be traced as a thickened cord as far as the sternum. Respiration 12 (the natural standard); pulse 50. _25th._ The parts around the vein much infiltrated with serum: pulse 55; respiration 12. _26th._ The wound in the neck began to suppurate, and an abscess subsequently formed in the course of the vein, about midway between the opening and the sternum. The general symptoms continued, with very slight variation, until the 4th of December, when the animal was destroyed. _Post-mortem appearances._ The jugular vein was found to have become inflamed only in the course of the circulation, and to be obliterated a short distance below the external opening. The surrounding parts were greatly infiltrated with serum and lymph, and several abscesses had formed in the immediate neighbourhood. The lungs did not present any well-defined patches of congestion, as in the last mentioned experiment. EXPERIMENT VIII. A healthy ass, six years old, was operated on upon the 16th of November, 1848. The respiration was naturally 14 in the minute, and the pulse 38. About two ounces of highly offensive pus, obtained from the frontal sinus of a horse, were injected into the left jugular vein; the pus had unintentionally been mixed with water previous to its being injected. The vein became full during the operation, as though the blood in it were in a semi-coagulated state. The pulse now became 60, and the respiration 20 in a minute; slight rigors occurred in two hours. _November 17th._ The animal is tranquil; appetite good; pulse 48, small and wiry; respiration 16. In the evening he was rather more excited; the vein was becoming inflamed downwards towards the heart; pulse 60; respiration 20.