They gladly consented to the trial, and a single drop of the spirituous tincture, equal to the one-twentieth part of a grain of extract, was placed on the child’s tongue at ten, p.m. No immediate effect was perceptible, and in an hour and a half two drops more were given. The infant fell asleep in a few minutes, and slept soundly till four, p.m., when she awoke, screamed for food, _took the breast freely_, and fell asleep again. At nine, a.m., 1st of October, I found the child fast asleep, but easily roused; the pulse, countenance, and skin perfectly natural. In this drowsy state she continued for four days totally free from convulsive symptoms in any form. During this time the bowels were frequently spontaneously relieved, and the appetite returned to the natural degree. October 4. At one, a.m., convulsions returned and continued at intervals during the day; five drop doses of the tincture were given hourly. Up to midnight there were thirty fits, and forty-four drops of the tincture of hemp were ineffectually given. 5. Paroxysms continued during the night. At eleven, a.m., it was found that the tincture in use during the preceding days had been kept by the servant in a small bottle with a paper stopper; that the spirit had evaporated and the whole of the resin had settled on the sides of the phial. The infant had in fact been taking drops of mere water during the preceding day. A new preparation was given in three drop doses during the 5th and 6th, and increased to eight drops with the effect of diminishing the violence, though not of preventing the return of the paroxysm. On the 7th I met Dr. Nicholson in consultation, and despairing of a cure from the hemp, it was agreed to intermit its use, to apply a mustard poultice to the epigastrium, and to give a dose of castor oil and turpentine. The child, however, rapidly became worse, and at two, p.m., a tetanic spasm set in, which lasted without intermission till half-past six, p.m. A cold bath was tried without solution of the spasm; the hemp was, therefore, again resorted to, and a dose of thirty drops, equal to one and a half grains of the resin, given at once. Immediately after this dose was given the limbs relaxed, the little patient fell fast asleep, and so continued for thirteen hours. While asleep, she was evidently under the peculiar influence of the drug. On the 8th October, at four, a.m., there was a severe fit, and from this hour to ten at night twenty-five fits occurred, and 130 drops of the tincture were given in thirty drop doses. It was now manifestly a struggle between the disease and the remedy; but at ten, p.m., she was again narcotised, and from that hour no fit returned.