The first effect of this class of drugs is a short temporary stage of exhilaration, more or less rapidly followed, according to the amount taken, by a stage of sleepiness or actual insensibility, which lasts longer than the stage of excitement, and this in turn is followed by a long period of depression. Like other members of its class, alcohol has a cumulative action, the residual quantities habitually taken accumulate and gradually affect the efficiency and well-being of the individual. A point that must always be borne in mind in giving any medicine is that not a few drugs have a curious tendency to induce a craving for their repetition. The amount of alcohol contained in some of the most commonly used of the alcoholic beverages is as follows: beer, 4 to 5 per cent.; hard cider, from 5 to 10 per cent.; claret, 8 to 11 per cent.; port, 9 to 22 per cent.; champagne, 10 to 15 per cent.; rum, gin, and strong liquors, 40 to 50 per cent.; whisky, 44 to 50 per cent.; brandy, 48 to 56 per cent. These alcoholic beverages are often made still more harmful by adulterations by ingredients in themselves harmful. A large percentage of alcohol is also found in bitters and patent medicines. We will consider the subject of alcohol under the following aspects: First, the question of alcohol as a food; second, the effects of alcohol on the digestive system and the metabolism; third, the effects of alcohol on the heart and the muscular system; and fourth, the effects of alcohol on the nervous system. _First, Is Alcohol a Food?_—The substances used as foods act in providing energy for muscular work, in maintaining the heat of the body, in building up of the tissues, and in saving the waste of the tissues. Moreover, a food which does harm to any organ, or to the system as a whole, when taken in moderate repeated quantities, becomes a poison for that individual. A food may be defined as any substance which, when absorbed into the blood, will nourish, repair waste, and furnish force and heat to the body, without causing injury to any of its parts or loss of functional activity. From any one of these four standpoints alcohol cannot be regarded as a food. The physiologic effects of alcohol and real food-stuffs are totally different. Fats, carbohydrates, and nitrogenous foods after mastication at once begin to be digested and assimilated, and to fulfil the true functions of a food by maintaining a natural temperature, pulse-rate, and tissue repair of the body, without any disturbance of its mental and physical functions and activities. Alcohol, on the contrary, is absorbed from the stomach unaltered by the digestive processes; circulated in the blood in its original form, it at once interferes with the ordinary activity of the brain and other organs, and, by its anesthetic action, hampers the mental and physical activities and interferes with the processes of metabolism.