The Rev. Mr. Scaife, assistant to the Rev. Dr. Greene, Dean of Salisbury, in his parish of Cottenham, Cambridgeshire, acquaints me, that the farmers in that neighbourhood lost, in 1746 and 1747, twelve hundred head of cattle, in 1751 four hundred and seventy; and tells me, that Mr. Ivett, Sayers, Moor, Dent, Lawson, chief farmers at Cottenham, Mr. Taylor, Sumpter, and Matthews, of his own parish of Histon, and the farmers of Wivelingham alias Willingham, unanimously declare, they never had one instance of a beast having the distemper twice. Mr. Thorpe, a farmer and grazier near Gainsborough in Lincolnshire, has had beasts recovered from the distemper, which have herded with cattle fallen ill afterwards, and never met with a single instance of a second infection. Mr. Lostie, an eminent surgeon at Canterbury, has inquired for me of the farmers and graziers in that part of Kent, and about Romney-Marsh; and from whence no belief of a second infection can be had. The Rev. Dr. Fountayne, Dean of York, writes me word, that no beast has been known, in his neighbourhood, to have had the distemper twice. And several persons from that county, and others, have told me the same thing. If the above testimony of persons of character and veracity, together with the concurrent persuasion of farmers in general, be allowed of, it must be determined, that there is no instance of a second infection. Supposing now it should appear, that this distemper is regularly, as in the natural way, tho’ in a milder manner, produced by inoculation, and that inoculation secures a beast also from a second infection; then undoubtedly inoculation will be recommendable. The very few trials made in England, and those not with the greatest exactness or propriety, will yet serve to put this matter out of all doubt. The Rev. Dean of York had five beasts inoculated, by means of a skein of cotton dipped in the matter, and passed thro’ a hole, like a seaton, in the dew-lap. Of these five, one cow near the time of calving died: the other four, after going thro’ the several stages of this contagious disease, recovered; two of which, being cows young with calf, did not slip their calves. All four have herded with distempered cattle a long while, and never had the least symptom of a second infection. Mr. Bewley, a surgeon of reputation in Lincolnshire, inoculated three beasts two years old, for Mr. Wigglesworth of Manton, in the dew-lap, and with _mucus_ from the nostrils. All three had the regular symptoms of the contagious distemper in a mild manner, recovered, and tho’ they herded a twelvemonth after with five or six distempered beasts, they never were the least affected. Mr. Bewley also declared to Mr. Thorpe, that there never was one instance produced, that he knew of, of a second infection.