The question of safety is a pertinent one. Thus, Munk[23] some years ago (1893) sounded a warning on this point which was later confirmed by Rosenheim.[24] Both of these observers reported that in dogs fed for some time on a low proteid diet, but with an abundance of carbohydrate and fat, there was after some weeks (6-8) a loss of the power of absorption from the alimentary tract, dependent not alone upon a changed condition of the epithelial cells of the intestine, but also upon a diminished secretion of the digestive juices, loss of body-weight, strength, and vigor, followed speedily by death. If these results were really due to the low proteid diet, they suggest a grave danger which must not be lightly passed by. Jägerroos[25] has likewise observed, experimenting on dogs, that there was, after some months, a striking disturbance of the intestines on a low proteid intake, which, however, was eventually traced to a distinct infection, and probably in no manner connected with the diminished amount of proteid in the diet. In these various experiments on dogs carried out by Munk, Rosenheim, and by Jägerroos, there was of necessity great monotony in the diet, and in Munk’s experiments no fresh meat at all was fed, but simply dried food. In other words, if the diet was in any sense responsible for the poor health of the animals, it is fully as plausible to attribute the results to the abnormal conditions under which the animals were kept as to any specific effect due to the low proteid intake. It is very essential that the food of dogs, as of men, shall fulfil all ordinary hygienic conditions. It must be not only of sufficient quantity for the true needs of the body, but it should also have the necessary variety with reasonable degree of digestibility, and proper volume or bulk. When these qualities are lacking, it is not strange if deviations from the normal gradually develop. That the low intake of proteid food could be responsible for the condition existing in Munk’s and Rosenheim’s experiments is not plausible; a view which is strongly reinforced by many observations, notably those of Albu[26] on a woman thirty-seven years old and weighing 37.5 kilos, who had followed a vegetarian diet for six years, and who while under Albu’s care for two years consumed only 34 grams of proteid per day, the total fuel value of the food being only 1400 calories per day. This woman was in nitrogenous equilibrium on 5.4 grams of nitrogen, and on this diet had freed herself from the illness to which she had long been subject.