Finally, taking the average daily excretion of nitrogen through the kidneys from November 10 to June 23, as a measure of the nitrogen metabolized daily, viz., 6.53 grams, and taking the body-weight at 70 kilos, it is plain to see that the nitrogen metabolized per kilo of body-weight throughout this experiment was 0.093 gram, closely similar to the result obtained with the first subject. In other words, both of these subjects, though widely different in body-weight, under different degrees of physical activity, and living on different forms of diet, seemingly required for the maintenance of equilibrium essentially the same amount of nitrogen per kilo of body-weight; viz., with the first subject 0.0947 gram, if we take the lower figure of the last two months, and 0.093 gram with the second subject. Regarding the fuel value of the daily food, Dr. Mendel with a body-weight of 70 kilos, during the second balance period, apparently utilized on an average 34.9 calories per kilo of body-weight daily, while the first subject, of 57 kilos body-weight, made use of only 28 calories per kilo. The fuel value of the daily food must, however, as is well known, vary greatly with differing degrees of physical activity, from which arises the necessity for corresponding variation in the amounts of non-nitrogenous foods ingested. * * * * * Dr. Frank P. Underhill, instructor in physiological chemistry in the Sheffield Scientific School, is another subject of experiment who volunteered to study on himself the effects of a lowered proteid intake. Prior to the experiment he was in the habit of eliminating from 16 to 16.5 grams of nitrogen per day through the kidneys, representing the usual 105 grams of proteid food metabolized. Dr. Underhill, at the beginning of the experiment, July 1, 1903, was twenty-six years of age and weighed 67.6 kilos. For a period of two weeks, from July 14 to August 2, he gradually reduced the intake of proteid food as well as the total amount of food consumed, doing this in part by diminishing the quantity eaten at breakfast, and in smaller measure at the two other meals of the day. During this period of two weeks, the urine and fæces were analyzed with the results shown in the accompanying table. Regarding the extent of proteid metabolism, it will be seen that the nitrogen content of the urine fell from 14.28 grams per day down to 5 to 6 grams per day. Having reached this level, the subject maintained it throughout the summer of 1903, occasional analyses being made to demonstrate the level of nitrogen excretion.