Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crossesCastle, William E. (William Ernest)
Science
Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses
Castle, William E. (William Ernest)
Heredity
The early generations include too few individuals to be of much
statistical value, but where the number of offspring rises to 500 or
over, the statistical constants acquire undoubted value. The data have
been given in the form of correlation tables which will repay careful
study. In the tables a single entry has been made for each individual
offspring in that row which corresponds with the _mean grade_ of its two
parents. Thus, if one parent were of grade 2 and the other of grade 2½,
the offspring would be entered in the row 2¼ along with the offspring
of parents both of grade 2¼. Offspring of parents whose mean grade fell
between the rows given in the tables were divided equally between the
adjacent rows, alternate litters being assigned to each. Thus, if the
mean grade of the parents were 2⅟₁₆, alternate litters of offspring would
be entered in row 2 and in row 2⅛.
PLUS SELECTION SERIES.
This series begins with pairs ranging in average grade from +1.87 to +3.
From these parents were obtained 150 young, which range in grade from +1
to +3, as is shown in Table 1. It will be observed that the lower-grade
parents have on the average lower-grade offspring than the higher-grade
parents. But in no case is the average grade of the offspring as great
as that of their parents. Thus 1.87 parents had 1.82 offspring (average
grade); 2.00 parents had 1.76 offspring; 2.25 parents had 1.87 offspring;
and so on to 3.00 parents, which had 2.35 offspring. There is a falling
back in grade or “regression” of the offspring as compared with their
parents, which increases in amount as the grade of the parents becomes
higher. (See column “Regression” in Table 1.) The parents of this first
generation were chosen because of their high grade. They were all
probably in grade above the general average of the population from which
they were selected. In the case of those which deviate most from the
general average the regression is greatest, as we should expect.
This phenomenon of regression, which is a very general one in cases
of selection, was first observed by Galton in selecting sweet-peas of
varying size from a mixed population. Later Johannsen, who repeated the
experiment with beans, found that by pedigree culture he was able to
break the mixed population up into pure lines within which, considered
singly, no regression occurred. We shall need later to return to this
subject and consider whether pure lines free from regression exist or can
be produced as regards the hooded pattern of rats.
Public-domain text, read in full here on John Shaqi.
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