Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crossesCastle, William E. (William Ernest)
Science
Piebald rats and selection : $b An experimental test of the effectiveness of selection and of the theory of gametic purity in Mendelian crosses
Castle, William E. (William Ernest)
Heredity
Returning to the examination of Table 1, since the high-grade parents
produce higher-grade offspring than do the low-grade parents, it is
evident that we might hope by further selection either to isolate a pure
line of high-grade rats which would be free from regression and therefore
stable, or else to advance the grade of the offspring still higher,
even though regression persists. As a measure of the extent to which
high-grade parents have high-grade offspring and _vice versa_, in each
generation, we may employ the well-known correlation coefficient. This
for Table 1 is 0.30.
The second generation in the plus series (Table 2) includes the offspring
of parents which appear as offspring of the higher grades in Table 1,
together with a few individuals which appear in Table 2 both as offspring
and as parents of other offspring, by reason of their having been mated
with generation 1 individuals and so having produced generation 1½
offspring, as explained on page 8. To obtain larger numbers of offspring,
several new pairs were added to the experiment in this generation, which
do not appear in Table 1 either as offspring or as parents, but which
were derived from the same general stock as the parents of generation 1.
Their inclusion here accounts for the very low range of the offspring
in Table 2, which extends from -1.00 to +3.75. The parents’ range (means
of pairs) extends from 2.00 to 3.12. The grand average of the parents is
2.52, that of the offspring is 1.92. The correlation between grade of
parents and grade of offspring is 0.32.
From this point on in the series no new stock was added and each
generation of offspring furnished the parents for the following
generation, except for the slight overlapping of generations when parents
of different generations were mated with each other, as has already been
explained.
In generation 3, Table 3, the parents ranged from 2.12 to 3.37 in grade,
the offspring from 0.75 to 4.00. The mean of the parents was 2.73, that
of the offspring 2.51. The degree of correlation between parents and
offspring is expressed by the coefficient 0.33 (a perfect correlation
would give 1.00).
In generation 4, Table 4, the selection of parents became considerably
more rigid; most of the parental pairs were of grade 3 or higher, their
average being 3.09. The average grade of the offspring was 2.73, their
range extending from 0.75 to 3.75. The correlation in this generation
fell very low, to 0.07, not because of a lessened regression but rather
because of a very high regression on the part of the offspring of
high-grade parents.
In generation 5, Table 5, the grade of the selected parents ranged from
2.75 to 4.12, its mean being 3.33. The offspring, showing the usual
regression, ranged from 0.75 to 4.25, their mean grade being 2.90. The
correlation between parents and offspring in this generation was 0.16.
The number of individuals comprising this generation of offspring was 610.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account