AMONG the ignorant, poisons have ever been closely associated with superstition, and thus we find in the dark ages, even among the more civilized nations of the West, a belief in the occult concerning those things the action of which they did not understand. To most of the poisonous herbs used by the ancients certain curious superstitions were attached. The mandrake, in particular, excited the greatest veneration on this account. It is supposed this plant is the same which the ancient Hebrews called Dudaïm. That these people held it in the highest esteem in the days of Jacob is evident from the notice of its having been found by Reuben, who carried it to his mother; and the inducement which tempted Leah to part with it proves the value then set upon this remarkable plant. It was believed to possess the property of making childless wives become mothers. Mandrake was among the more important drugs employed by the ancients for producing anæsthesia. Doses of the wine made from the root were administered before amputating a limb or the application of the hot iron cautery. Pliny says: "Mandrake is taken against serpents, and before cutting and puncture, lest they be felt. Sometimes the smell is sufficient." According to Apuleius, half an ounce of the wine would make a person insensible even to the pain of amputation. Lyman states it was this wine, "mingled with myrrh," that was offered to the Saviour on the Cross, it being commonly given to those who suffered death by crucifixion to allay in some degree their terrible agonies. In Shakespeare's time mandrake still kept its place in public estimation as a narcotic. Thus we have Cleopatra asking for the drug, that she may "sleep out this great gap of time" while her Antony is away; and Iago, when his poison begins to work in the mind of the Moor, exclaims-- "Not poppy, nor mandragora Nor all the drowsy syrups of this world, Shall ever medicine thee to that sweet sleep."