In my opinion, the answer to this question may be given as follows: In the first place, we know that the primary effect of the compressed air upon the organism must be to force the blood from the surface of the body toward the interior, and especially into the cerebro-spinal canal. Or, to express it more succinctly, the blood will be forced in the direction of the least resistance, that is, into the soft organs inclosed by bony walls, which latter completely shut out the element of counter-pressure. Now, when the blood stream is freighted with a soluble chemical of some sort--let us say, for the present, with alcohol--this medicated blood will exert its greatest chemical effect where the tension--the pressure--is greatest, that is, in the cerebro-spinal canal. The reason for this is found in the fact that endosmosis is most pronounced where the blood pressure is greatest. This explanation of why the effects of alcohol are enhanced by exposing the individual who has taken it to the effects of a condensed atmosphere will, I believe, appeal to the physiological conceptions of most medical men. It was the above course of reasoning which, at this stage of the argument, led me to the idea that, just as the effects of stimulating substances are enhanced by exposing the subject to the influence of compressed air, so, inversely, sedatives and analgesics, when brought in solution into the blood stream, either hypodermically or by the stomach, might be greatly enhanced in effect by causing the subject to remain, while under their influence, in a condensed atmosphere. When I came to investigate the validity of these predictions, as I did shortly after the introduction of antipyrin, phenacetin, and the other members of the same group of compounds, I found my predictions verified, and, indeed, exceeded. To summarize the whole matter, I ascertained that not only could therapeutic effects be obtained from much smaller doses by exposing the subject to the influence of a condensed atmosphere, but, what was of equal interest, I found that the analgesic influence of the remedies was much more permanent, was prolonged, in short, by this mode of administration. When we consider how great must be the nutritive changes in the nervous system, and especially in the cerebro-spinal axis, consequent upon increasing the blood pressure in this way, I hardly think that these things should be matters of astonishment.