The first case of influenza in Indiana, Pa., of which there was any definite knowledge occurred on September 15. A clothing merchant who had just arrived from New York, where he had been buying stock for his store, was the first case identified. The next case occurred several weeks later, the disease being contracted at the mining town of Coal Run, in Indiana County. A man resident in Sharpsburg who had suffered from influenza visited friends in Fraser Township, Allegheny County, to convalesce. Previous to his coming that section had been free from the disease. He was still coughing at the time, and, moreover, he is said to have been a great talker and visited largely among the neighbors of his host. Threshings in that part of the township were going on and these he also attended. The date of his coming was October 13. By October 15 his hostess was taken ill. By October 16 some of the threshers were affected, and by October 17 enough were sick to break up the work of threshing. Eventually all the men engaged became ill, and 11 families were infected from this source. _Summary_ Reviewing the history of former epidemics and pandemics, I have gained the impression, as have many others, that we are not dealing with any new disease. Further, our knowledge of this pandemic with its high incidence of broncho-pneumonia shows that it is in no way markedly different from that of former manifestations of influenza. One is impressed by the fact that in different outbreaks of this disease of complex symptomatology certain symptoms or complications have been prominent, overshadowing others, and making such complications the striking feature at the time. The failure to recognize that these varying features are merely different manifestations of one disease has resulted in much confusion. The observation made in the last epidemic—and one which can be endorsed during the present plague—is that influenza has been and is the most widespread, rapid and extensive of all diseases. One thing also that attracts attention at the present time is the long period existing between the several pandemics. Whether, as one observer during the present pandemic has stated, it requires a long period for the infection to become active and easily carried, or whether any possible reason can be suggested for these phenomena, admits of no satisfactory explanation. The outstanding feature during this epidemic is the complication of broncho-pneumonia, and yet, from very early times, this complication has been repeatedly spoken of as a striking characteristic. Reviewing the health reports from the large cities of deaths from pneumonia, the presumptive opinion seems justified that almost all, if not all, pneumonias reported as associated with influenza were of the broncho-pneumonia type. The infrequent presence, indeed the rare finding, of lobar pneumonia during this period in Pittsburgh seems to verify the aforesaid opinion.