I am myself no authority on the subject concerning which you write. I drink myself, but not during the hours of work; and I smoke-pretty habitually. My own experience and belief is, that both alcohol and tobacco, like most blessings, can be turned into curses by habitual self-indulgence. Physiologically speaking, I believe them both to be invaluable to humankind. The cases of dire disease generated by total abstinence from liquor are even more terrible than those caused by excess. With regard to tobacco, I have a notion that it is only dangerous where the vital organism, and particularly the nervous system, is badly nourished. ROBERT BUCHANAN. March 7, 1882. DR. BUDDENSEIG, DRESDEN. I have no decided opinion whatever as to the question you ask. I can only say that I am a very small smoker, taking one or two cigars daily, and I drink Rhine wine, but not daily, as most scholars or those working with their brains generally do. There can be, I should think, no question that immoderate use of alcohol produces most destructive results. E. BUDDENSEIG. Feb. 20, 1882. CAPTAIN FRED BURNABY. In my humble opinion, every man must find out for himself whether stimulants are a help to his intellectual efforts. It is impossible to lay down a law. What would, perhaps, enable one man to write brilliantly would make another man write nonsense. I myself, although not an abstainer, should think it a great mistake to seek inspiration in either tobacco or alcohol. F. BURNABY. March 2, 1882. LIEUT.-COL. W. F. BUTLER. In reply to your communication, asking for a statement of my experience as to the effects of tobacco and alcohol upon the mind and health, I beg to inform you that as I have not been in the habit of using the first-named article at any period of my life, I am unable to speak of its effects, mental or otherwise. With regard to alcohol, I have found that although the brain may receive a temporary accession to its production of thought, through the use of wine, etc., such increased action is always followed by a decided weakening of the thinking power, and that on the whole a far greater amount of _even_ mental work is to be obtained without the use of alcohol than with it. W. F. BUTLER. Feb. 18, 1882. DR. LAUDER BURNTON, F. R. S. I am unable to give you personal experience as to the use of tobacco, inasmuch as I do not use it in any form. From observation of others it appears to me that, when not used to excess, it is serviceable both as a stimulant during work, and as a sedative after work is over. LAUDER BURNTON. Feb. 9, 1882. MAXIME DU CAMP.