I have never been able to make any experiences on the influence of alcohol upon the mind. I never drink it, and have never been tipsy. I smoke very much, but only the pipe and cigarette. I take two meals every day--one at eleven, consisting of a mutton chop, vegetables, and a cup of tea. I make a hearty dinner at seven, and drink a bottle of Bordeaux wine. I never work in the evening; and go to bed at half-past ten. I think the use of tobacco very useless and rather stupid. As to alcohol, I consider it very hurtful for the liver, and highly injurious to the mind. The life of mental workers should be well regulated and temperate in all respects. Bodily exercises, such as riding, walking and hunting, are very necessary for the relaxation of the mind, and must be taken occasionally. In my opinion, all intellectual productions are due to a special disposition of the cerebro-spinal system, upon which tobacco and alcohol can have no salutary action. I fear that my answer will be of little help to you; for in these matters I esteem theory nothing. There are, as the Germans say, _idiosyncrasies_. MAXIME DU CAMP. Feb. 17, 1882. DR. W. B. CARPENTER, C. B., LL. D., F. R. S. In reply to your enquiry, I have to inform you that I have never felt the need of alcoholic stimulants as a help in intellectual efforts; on the contrary, I have found them decidedly injurious in that respect, except when used with the strictest moderation. For about eleven years of the hardest-working period of my life, that in which I produced my large treatises on Physiology, edited the Medical Quarterly Review, and did a great deal of other literary work, besides lecturing, I was practically a total abstainer, though I never took any pledge. I undoubtedly injured myself by over-work during that period, as I have more than once done since under the pressure of official duty; but the injury has shown itself in the failure of appetite and digestive power. After many trials, I have come to the practical conclusion that I get on best, while in London, by taking with my dinner a couple of glasses of very light Claret, and simply as an aid in the digestion of the food which is required to keep up my mental and bodily power. But when "on holiday" in Scotland, or elsewhere, I do not find the need of this. I have never smoked tobacco, or used it in any form. I need scarcely say that I have never used any other "nervine stimulants." You are at perfect liberty to make use of this communication. WM. B. CARPENTER. Feb. 17, 1882. MR. WILLIAM CHAMBERS, LL. D. In reply to your note, I have only time to say that I never used tobacco in any form all my life, and I can say the same thing regarding my brother, Robert. WILLIAM CHAMBERS. February 10, 1882. MR. GEORGE W. CHILDS, PHILADELPHIA.