Fothergill ordered him to resume its use. Charles Wesley began to abstain, but how long his abstinence lasted we are not informed. About 100 of the London Methodists followed the example of their leader; and, besides these, a large number of others began to be _temperate_ and to use less than they had previously." "This was, to say the least," adds Mr. Tyerman, "an amusing episode in Wesley's laborious life. All must give him credit for the best and most benevolent intentions, and it is right to add that, ten days after his proposal was submitted to the London Society, he had collected among his friends thirty pounds for a lending stock, and that this was soon made up to fifty, by means of which, before the year was ended, above 250 destitute persons had received acceptable relief." The most noteworthy opponent after Wesley was Jonas Hanway, who, in 1756, wrote a bulky volume under the title of "A Journal of Eight Days' Journey from Portsmouth to Kingston-upon-Thames, to which is added an Essay on Tea, considered as Pernicious to Health, obstructing Industry, and impoverishing the Nation." The effects of tea-drinking formed the subject of Dr. Lettsom's inaugural thesis, when he sought the medical doctorate of the University of Leyden in 1767. He accused tea of inducing "excess in spirituous liquors, by reason of the weakness and debility of the system brought on by the daily habit of drinking tea, seeking a temporary relief in some cordial; of producing in some excruciating pains about the stomach, involuntary trembling and fluttering of the nerves, destruction of half your teeth at the age of twenty, without any hopes of getting new ones, depression, loss of memory, tremblings and symptoms of paralysis; and of bringing on a gradual debility and impoverished condition of the entire system." Tea contains an active principle called _theine_, which, according to Dr. Sinclair, was discovered so recently as 1827. Adopting one of the methods of the opponents of tobacco, the enemies of tea conclude it to be a deadly poison from its effect upon animals. A New York dentist is reported to have boiled down a pound of young Hyson tea from a quart to half a pint, ten drops of which killed a rabbit three months old; and when boiled down to one gill, eight drops killed a cat of the same age in a few minutes. "Think of it!" exclaims an opponent of tea, "most persons who drink tea use not less than a pound in three months, and yet a pound of Hyson tea contains poison enough to kill, according to the above experiment, more than 17,000 rabbits, or nearly 200 a day! and if boiled down to a gill, it contains poison enough to kill 10,860 cats in the same space of time! How can any one in his senses believe that any human being can take poison enough into the stomach in one day to kill 185 rabbits and not suffer from it?--or that the uses of this poison can be continued from day to day without injury to health and life?"[5]