_Symptoms._ As a rule the disease occurs in pampered, overfed and obese animals, and in those of the improved breeds which have great power of digestion, assimilation and fattening. It is especially to be looked for after close confinement on full, stimulating, amylaceous diet. Symptoms are not usually recognized during life. There is, however, a lessening of the urinary secretion, and, as the disease advances, albuminuria. When examined microscopically this is found to contain characteristic elements, such as granular epithelial cells, the granules soluble in ether, oil globules, and at times crystals of cholesterine (Beale). A diagnosis based on the mere presence of oil globules may, however, be fallacious, as these may be present in animals that have just been heavily fed on oleaginous food, and again the oil used to smear the catheter may float in the urine and prove misleading. Under such circumstances vaseline or glycerine may be substituted on the catheter. Scriba induced fatty urine by injecting fat or oil emulsion into the blood, and Chabrie by ligating the large intestine. Trasbot says that cylindroid casts may be present. As in other grave kidney affections, dropsies supervene as the disease advances. These may show in the limbs, in the abdomen, or in other serous cavities. A steadily advancing anæmia with pallor of the mucosæ, listlessness, weakness, debility and sluggishness are to be noted. _Prognosis._ Since the disease is rarely diagnosed until it has reached an advanced stage, it usually progresses steadily to a fatal issue. If, however, it can be detected at an earlier stage, it may be palliated, or held in abeyance, for a length of time varying with the extent of the lesions. As it is very largely a disease of meat producing animals and as the subject is at first in a condition of marked obesity, it can usually be turned over to the butcher without material loss. _Treatment._ If the disease has resulted from the inbred propensity to fattening, the family that shows the disposition must be subjected to a somewhat different regimen, open air exercise must take the place of confinement in warm stables, a rather bare pasturage is valuable for herbivora, and a restricted diet in which the oleaginous, saccharine, and amylaceous constituents do not predominate, is strongly indicated. Crossing with a strange male having many of the desirable qualities of the herd, but which is more vigorous may be resorted to. When the secretion of urine becomes scanty an abundance of pure water, or a diet of succulent grass or roots or ensilage or even small doses of alkaline diuretics may be resorted to. Any source of arsenic or phosphorus poisoning should be cut off, and as an antidote to phosphorus, oil of turpentine may be given in small doses. This agent may, indeed, replace the alkalies as a diuretic, bringing in an element of tone for the mucosa which is not to be despised. Or balsam of copaiba or buchu leaves may be substituted.