6. Similarly, the facts which have in recent times been ascertained in reference to the remarkable influence exerted by the so-called “internal secretion” of certain ductless glands on the general metabolism, the part played by the pancreas in reference to the transformations of sugar in the body indicate yet other lines of research to be carried out in connection with the main inquiry. In conclusion: The final problem of the work of the proposed Laboratory will be to ascertain the conditions which will “render it possible to obtain from the human machine, under varying conditions, the highest efficiency at the least cost.” The value of results which may be thus obtained, considered from the point of view of social, political, and administrative economy, is hardly to be exaggerated. SUGGESTIONS AS TO STAFF AND PERSONNEL OF THE PROPOSED INTERNATIONAL LABORATORY For the coördination and general direction of the several investigations, the services of an eminent physiological chemist (preferably one having the principal European languages at his command) is essential. Such a director would need at least two efficient permanent technical assistants, as for instance, one to deal with the problems of Organic Chemistry, and another competent to deal with the problems of Physical Chemistry. Other assistants might be necessary, but it would probably be desirable that the Institute should have the power of subsidising, for a longer or shorter period, men who would undertake special investigations in coördination with the general work, and who would thus be, as it were, temporary assistants. This would be quite apart from the general hospitality of the Laboratory offered by the Institute to other investigators. ESTIMATES FOR THE PROPOSED LABORATORY INITIAL OUTLAY Director $5,000 $5,000 Permanent and Temporary Assistants 7,500 to 10,000 Other General Maintenance 5,000 to 7,500 ——————— —————— — $17,500 $22,500 With regard to the second item, the permanent assistants would be required at the outset, but the temporary assistants would be taken on as opportunity offered. Less than even the lower estimate might suffice at first. Regarding the third item, also, the maximum might not be required in the beginning. SUGGESTIONS AS TO DESIRABILITY OF LOCATION