Actions and Uses.—Brometone is claimed to have the sedative action of the bromides without the disadvantage of producing bromism. In doses of 0·3 gramme (5 grains) four or five times a day, in adults, it is claimed to cause no unpleasant results and to produce no disturbance of the digestive organs, and to have no appreciable effect on the secretions. Its action is prompt and its effect is manifest for several hours. In doses exceeding 1·6 grammes (25 grains) daily it may produce dizziness, vertigo, anorexia, and mental hebetude, all of which symptoms disappear on discontinuance of its use. Therapeutically it has been recommended in mild conditions of excitation and insomnia, in so-called narcotic abstinence, in hysteria, and in nervous affections generally. It relieves some forms of cough and is said to produce amelioration in about 60 per cent. of cases of epilepsy. It has been used to relieve dizziness due to labyrinthine disturbances. Dosage.—The dose is 0·3 gramme (5 grains), to be repeated two or three times during twenty-four hours. Manufactured by Parke, Davis & Co., Detroit, Mich. BROMIPIN. A bromine addition product of sesame oil, containing 10 per cent. of bromine in organic combination. Actions and Uses.—Bromipin acts like the bromides, but as it yields its bromine more slowly it is thought to have less tendency to produce brominism. The combination is not broken up in the stomach, but a portion of the bromine is split off as soon as the oil enters the intestine. The oil with the remaining bromine is easily absorbed, and, similarly to other fats, is largely deposited in the tissues, where it is slowly split up. It is said to be more lasting in its action than the bromides. Dosage.—4 c.c. (1 fluidrachm), increased in cases of epilepsy to from 8 to 32 c.c. (2 to 8 fluidrachms); in emulsion with peppermint water and syrup, or pure, flavored with oil of peppermint. Manufactured by E. Merck, Darmstadt. (Merck & Co., New York.) BROMIPIN—33⅓ PER CENT. A 33⅓ per cent. brominized sesame oil. Manufactured by E. Merck, Darmstadt. (Merck & Co., New York.) BUTYL-CHLORAL HYDRATE. Actions and Uses.—Its action is similar to that of chloral, except that it is said to be less depressing and more analgetic. It has been especially recommended for facial neuralgia. Dosage.—0·3 to 1·3 grammes (5 to 20 grains). CALCIUM ICHTHYOL. A derivative of ichthyol in which calcium is substituted for ammonium. Manufactured by the Ichthyol Company, Hamburg. (Merck & Co., New York.) CALOMELOL. A soluble colloidal form of calomel, containing albuminoids.