Mr. COLERIDGE’S CASE.—“The first time I inspired the nitrous oxide, I felt an highly pleasurable sensation of warmth over my whole frame, resembling that which I once remember to have experienced after returning from a walk in the snow into a warm room. The only motion which I felt inclined to make, was that of laughing at those who were looking at me. My eyes felt distended, and, towards the last, my heart beat as if it were leaping up and down. On removing the mouth-piece, the whole sensation went off almost instantly. “The second time, I felt the same pleasurable sensation of warmth, but not, I think, in quite so great a degree. I wished to know what effect it would have on my impressions: I fixed my eye on some trees in the distance, but I did not find any other effect, except that they became dimmer and dimmer, and looked at last as if I had seen them through tears. My heart beat more violently than the first time. This was after a hearty dinner. “The third time, I was more violently acted on than in the two former. Towards the last, I could not avoid, nor indeed felt any wish to avoid, beating the ground with my feet; and, after the mouth-piece was removed, I remained for a few seconds motionless, in great ecstasy. “The fourth time was immediately after breakfast. The first few inspirations affected me so little, that I thought Mr. Davy had given me atmospheric air; but soon felt the warmth beginning about my chest, and spreading upward and downward, so that I could feel its progress over my whole frame. My heart did not beat so violently; my sensations were highly pleasurable, not so intense or apparently local, but of more unmingled pleasure than I had ever before experienced.” * * * * * Dr. KINGLAKE’S CASE.—“My first inspiration of it was limited to four quarts, diluted with an equal quantity of atmospheric air. After a few inspirations, a sense of additional freedom and power (call it energy, if you please) agreeably pervaded the region of the lungs; this was quickly succeeded by an almost delirious but highly pleasurable sensation in the brain, which was soon diffused over the whole frame, imparting to the muscular power at once an increased disposition and tone for action; but the mental effect of the excitement was such as to absorb in a sort of intoxicating placidity and delight, volition, or rather the power of voluntary motion. These effects were in a greater or less degree protracted during about five minutes, when the former state returned, with the difference however of feeling more cheerful and alert, for several hours after.