The writer of the annotations began his work in that clear Italian hand which came into vogue in the reign of James I., (see, for instance, Gethinge, Plates 18 to 28,) of which fac-simile No. 1, "_Experience of father_" is an example. In the course of the first few pages, however, his chirography, on the one hand, shows traces of the old English chancery-hand, and, on the other, degenerates into a careless, cursive, modern-seeming style, of which fac-simile No. 2, "_England_," is a striking instance. But he soon corrects himself, and writes for twenty folios (to the recto of folio 27) with more or less care in his clear Roman hand. Thence he begins to return rapidly, but by perceptible degrees, to the old hand, until, on the recto of folio 31, and a page or two before it, he writes, illegibly to most modern eyes, as in fac-simile No. 3, "_a proverbe_." Thereafter, except upon certain rare and isolated occasions, he never returns to his Italian hand, but becomes more and more antique in his style, so that on folio 65, and for ten folios before and after, we have such writing as that of fac-simile No. 4, "_strangers where they come change the speech there used_." On folios 93 to 95 we find characters like those given in fac-simile No. 5, which it requires more experience than ours in record-reading entirely to decipher. On the reverse of folio 95 the annotator, apparently weary of his task, stayed his hand. Now in these ninety-nine folios (including the Preface, which is not numbered) are not only all the five varieties of chirography fac-similed above, but others partaking the character of some two of these, and all manifestly written by the same hand; which is shown no less by the phraseology than by the chirographic traits common to all the notes. And besides, not a few of these notes, which fill the margins, are in Latin, and these Latin notes are always written in the Italian hand of fac-simile No. 1; so that we find that hand, in which all the notes, English and Latin, (with a few exceptions, like "_England_,") are written for the first twenty-seven folios, afterward in juxtaposition with each of the other hands. For instance, on folio 87, recto, we find "_tolerare laborem propter virtutem quis vult si praemia desunt_," written in the style of "_Experience_" No. 1 above, though not so carefully, and immediately beneath it, manifestly with the same pen, and it would seem with the same pen-full of ink, "the saying of Galen," in the style of No. 4, "_strangers where they come_," etc.