3.—Following then the course of nature, and already sixty-five years old,[29] he died gloriously, as he had lived; and he left as his successor a motherless little boy of ten years, his only son Guidobaldo. Heir to the State, he seemed to be heir also to all his father’s virtues, and soon his noble nature gave such promise as seemed not permissible to hope for from mortal man; so that men esteemed none among the notable deeds of Duke Federico to be greater than to have begotten such a son. But envious of so much virtue, fortune thwarted this glorious beginning with all her power; so that before Duke Guido reached the age of twenty years, he fell ill of the gout,[30] which grew upon him with grievous pain, and in a short space of time so crippled all his members that he could neither stand upon his feet nor move; and thus one of the fairest and most promising forms in the world was distorted and spoiled in tender youth. And not content even with this, fortune was so contrary to him in all his purposes, that he could seldom carry into effect anything that he desired; and although he was very wise of counsel and unconquered in spirit, it seemed that what he undertook, both in war and in everything else whether small or great, always ended ill for him. And proof of this is found in his many and diverse calamities, which he ever bore with such strength of mind, that his spirit was never vanquished by fortune; nay, scorning her assaults with unbroken courage, he lived in illness as if in health and in adversity as if fortunate, with perfect dignity and universal esteem; so that although he was thus infirm of body, he fought with most honourable rank in the service of their Serene Highnesses the Kings of Naples, Alfonso[31] and Ferdinand the Younger;[32] later with Pope Alexander VI,[33] and with the Venetian and Florentine signories.