Mustard plasters to limbs and over the heart should be given when there are signs of failing heart and circulation, and over the epigastrium when there is vomiting or hiccough. Smelling salts and strong ammonia should be applied to the nostrils for their restorative action. Blister over the nape of the neck is useful when cerebral symptoms are present. Ice caps over the head is very useful and should be applied continuously. The enlarged glands may be fomented with hot water or spongio-piline wrung out of hot antiseptic solution. When they are much painful, poppy or belladonna may be added to the water. Belladonna with glycerine should be applied in the beginning and iodine afterwards. Hot corrosive sublimate fomentations are also useful. If the glands suppurate, they should be opened aseptically and dressed with antiseptics. Proper drainage should be provided. IV. _Internal._—Knowing as we do that the plague is due to the toxic products metabolized by a pathogenic bacillus, the question comes—would an antiseptic treatment be of any use? Can we by any means induce an antiseptic action on the blood, or have we any drug which can act as antitoxin? It must be at once stated that no drug that has been tried yet fulfils the above conditions. The claims of quinine, however, should be taken into account. This drug in small repeated doses acts as a general antiseptic. I would, therefore, advocate its use especially in the early stages. Plague is a disease in which collapse sets in early and cardiac asthenia is a very early complication. There is, therefore, great urgency for early stimulation. Alcohol may be given freely, but at the same time it must be remembered that if the organs of elimination are not acting properly, alcohol may do harm. For their stimulant effects whiskey or iced champagne may be given. Carbonate of ammonia or spirit ammonia aromatic are held to be very useful stimulants in plague cases. They may be given in combination with cinchona, digitalis and ether. A prescription like the following may be useful:— Ammonia Carb. 5 grains. Chloric Ether 20 minims. Sulphuric Ether 15 ” Tint. Digitalis 5 ” Tint. Cinchona 1 dram. Aquæ Camphor 1 ounce. Every three hours. For cardiac asthenia, the following may be tried:—(1) Caffeine, hypodermically, 5-grains dissolved by the aid of 5 grains of Sodium Benzoate in 20 minims of warm distilled water and injected three or four times a day if needful; (2) Ether or ethereal solution of camphor hypodermically; (3) Strychnine, hypodermically, beginning with gr. 1/60 every four or six hours till gr. 1/16 is injected, or Liquor Strychnia in 5—10-minim doses every four hours; (3) Musk may be given in 5-grain doses, or as in the following mixture:—