Pulv. Moschi 10 grains. Mucilage Acacia 2 drams. Syr. Aurantii 2 ” Aquæ Camphor ½ ounce. To be given every 6 hours. Digitalis does not always give good results, a fact which Lowson attributes to some inflammatory or fatty degenerative changes in the small vessels giving rise to a tendency to hæmorrhage. Stropanthus may be substituted. Transfusion of blood a hot saline solution and inhalation of oxygen have been recommended for collapse. Dr. Viegas of Bombay recommends Liquor Hydrasgyie Perchloride 10 to 15 minims every four hours if there is no albumen in the urine. Dr. Dimmock has advised subcutaneous injection of Guaicol 10 or 15 minims every two hours. Permanganate of Potash 5 to 12 grains in 24 hours has also been recommended. Dr. Blaney has recommended Medritina in two-dram doses every two hours when the kidneys are involved. Camphor has been recommended by some as a cardiac stimulant. _TREATMENT OF SYMPTOMS._ (1). High temperature may be reduced by antipyretics, such as antipyrin, phenacetin, antifebrine, &c. These drugs produce profuse perspiration and a certain amount of depression; it is, therefore, advisable to restrict their use during the first few hours only, and if not found responding, they should be dropped altogether. Pyrexia is but a sign of the intensity of the activities of the infective agent, and by artificially reducing the body heat we really do not lessen the virulence of the poison, as shown by the rise of the temperature again as soon as the action of the antipyretic subsides. Hyperpyrexia itself is, however, an injurious symptom, and when there is long continued high temperature it is necessary to reduce it, either by an antipyretic, quinine or cold bath, or cold sponging. Cold bath is not suitable in plague patients on account of the movement of the body which it entails, and also on account of the serious cardiac depression which accompanies the disease. Two grains of phenacetin with 1 grain of hydrobromate of quinine is a safe antipyretic. Brandy and tepid sponging are also very useful. (2). _Brain symptoms._—For headache a mustard plaster behind the upper part of the neck and over the occiput. Ice cap or Lieter’s tube or plain water should be applied over the temples and scalp. Nervine sedatives, such as Potassium Bromide, may be given for insomnia when there is not much depression. Otherwise full doses of alcohol may be tried. Opium should not be used, but in mild cases, without great depression, 10 to 20 minims of Liquor Opii sedativus with 30 minims of Sal Volatile in an ounce of camphor water may be given to soothe nervous unrest. For insomnia Lowson speaks highly of Morpinæ gr. 1/8 to gr. ½. Hyoscine gr. 1/200 to gr. 1/75 may be tried. Meningites should be treated by cold to the scalp and counter-irritation to the nape of the neck and occiput.