The Chemical Constituents of Piper Methysticum: Or, The Chemical Constituents of the Active Principle of the Ava RootBall, Alice A.
Science
The Chemical Constituents of Piper Methysticum: Or, The Chemical Constituents of the Active Principle of the Ava Root
Ball, Alice A.
Kava plant
The free acids were removed by shaking the total resins successively
with solutions of one percent ammonium carbonate, one percent
sodium carbonate and one percent sodium hydroxide. The acids thus
removed were recovered by treating the alkaline solution with dilute
hydrochloric acid and shaking out with ether. The three acids were not
markedly different in their physical properties. They possessed the
characteristic odor of the crude drug, were viscous, brown in color
and did not solidify at minus ten degrees Centigrade. These free acids
constitute about five percent of the total resins.
The remainder of the extract was treated with alcoholic potassium
hydroxide and saponified by heating the solution to about eighty
degrees for fifteen minutes. After the alcohol was removed by
distillation a small quantity of water was added. This resulting
solution was then extracted with ether to remove the alcohol radical or
radicals and the unsaponifiable material from the saponified product.
The ether extract was saved to be used in the work on the alcohol
radicals. The aqueous portion was evaporated to a semi-solid mass.
Carbon dioxide was passed over this mass for about fifteen minutes
to change any excess of potassium hydroxide to potassium carbonate.
Alcohol (95%) was then added to precipitate the carbonate. The
carbonate was then filtered off and water added to the filtrate.
To the clear filtrate a solution of barium chloride was added.
Immediately a dense thick cream yellow precipitate formed. Barium
chloride was added in excess. The barium salt was filtered off by
means of a suction pump and the precipitate washed with water. The
filtrate was treated with a few drops more of barium chloride so as to
be sure that an excess had been added, which was proven if no further
precipitate formed. To this clear filtrate an excess of a solution of
ferric chloride was added. Immediately a thick heavy precipitate of the
iron salt came down, which was filtered off by means of a suction pump
and the precipitate washed with water.
The barium precipitate was treated with dilute hydrochloric acid and
heated to boiling to decompose the barium resinate, and to liberate
the free resin acid. The liberated acid was a brown resin of a thin
consistency and had a characteristic odor. This acid was removed by
shaking out with ether. The ethereal solution was dried with anhydrous
sodium sulphate, filtered, and the ether removed by distillation. The
last traces of ether were removed by heating the resin acids in a
vacuum oven at sixty five degrees Centigrade. This resinous acid is the
acid spoken hereafter in this paper as the BARIUM ACID.
Public-domain text, read in full here on John Shaqi.
Reviews
Reviews
No reviews yet
Be the first to share your thoughts on this work.
Join the Discussion
Join the discussion
Sign in to leave a comment or review.
Sign InorCreate an account