The Chemical Constituents of Piper Methysticum: Or, The Chemical Constituents of the Active Principle of the Ava RootBall, Alice A.
Science
The Chemical Constituents of Piper Methysticum: Or, The Chemical Constituents of the Active Principle of the Ava Root
Ball, Alice A.
Kava plant
An attempt was made to make the potassium salts of the barium acids by
saponification with alcoholic potash. A small quantity of the acid was
treated with an excess of ten percent alcoholic potash and heated to
eighty degrees Centigrade to complete the saponification. Instead of
the formation of the potassium salts, a thick dark brown solid, gummy
mass separated. On cooling it solidified to a brittle solid which had
all the physical properties of a true resin. This solid is soluble
in ether, chloroform and benzol, slightly soluble in alcohol and
insoluble in petroleum ether and water. It burns without the formation
of an ash. Evidently, this brittle material is a condensation product
of the original barium acid.
_OXIDATION PRODUCTS OF THE BARIUM ACIDS._
A small amount of the Barium acids was sealed with concentrated nitric
acid in a hard glass tube and heated in a bomb furnace for an hour
and a half at 115 to 120 degrees Centigrade. On cooling a yellow
solid separated. Qualitative tests showed that this oxidation product
contained no nitrogen, combined with sodium hydroxide readily, is
soluble in hot water, slightly soluble in cold water, easily soluble in
ether, alcohol and benzol and slightly soluble in carbon tetrachloride.
It decolorizes alkaline permanganate but does not decolorize bromine
water.
That there are a number of intermediate products formed and that
nitration also takes place during the formation of these intermediate
products is shown by the following. A small quantity of the acids were
placed in a test tube and covered with concentrated nitric acid. This
was suspended in an H2SO4 bath and a thermometer inserted so as to
observe the temperature. On being gently warmed the nitric acid and
the resin began to react with a rapid evolution of carbon dioxide and
oxides of nitrogen. As soon as the reaction had modified and before the
temperature rose above one hundred degrees Centigrade, a small amount
was removed and added to water. Some of the solid acid was formed and
also a number of globules of oil and there was a strong persistent odor
of nitrobenzene. The original test tube was heated to about one hundred
and twenty degrees centigrade and a small portion again removed. There
was more of the solid material formed and the odor was similar to
vanillin or coumarin or cinnamic aldehyde. The test tube was again
tested when the temperature had reached one hundred and thirty five
degrees Centigrade. There was no aromatic odor and a large amount of
the solid formed. When viewed under the microscope the substance had
the appearance of curled threads.
When the barium acids were treated with the standard nitrating mixture,
a solid was obtained which showed the presence of nitrogen when the
standard test was applied.
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