In the treatment of this disease, recourse has been had to almost every remedy favourably reported of by European practitioners, and they all have had, for a time, their advocates--some preferring stimulants, others opiates, while others satisfied themselves with an intermediate plan of treatment--the whole of the medical practitioners with one accord agreeing, however, in the application of external stimulants, such as oil of turpentine, mustard, warm applications and frictions; calomel and opium have been much relied on by many. Practitioners speak with confidence of blood-letting at the onset of the disease, and before an approach to collapse has been recognised. Sweating has been much practised, and decidedly with advantage, when it is not allowed to run into that state of collapse indicated by a pulseless wrist, dejected countenance, blue extremities, tongue and breath cold, and a sunken voice, feeling as if it passed through the ears. Some instances have been noticed, and also observed by our intelligent clergy, as well as by ourselves, where, in some mild forms of the disease, nature effected a cure by copious perspiration, encouraged by warm drinks and extra clothing. The undersigned, with one accord, have found purgatives injurious, if used before perspiration or blood-letting had been resorted to, to allay the irritable state of the stomach and bowels; and then only the milder purgatives should be employed, such as calomel or blue pills, guarded with minute doses of opium, and carried off, after a few hours, with rhubarb, combined with soda and carbonate of ammonia. Signed, Jos. Morrin, Health Commissioner; W. A. Hall, Resident Physician; F. X. Tessier, Health Officer; Wm. Lyons, Superintendent of the Emigrant Hospital. _Origin of the Cholera at Sunderland._ By T. M. GREENHOW, Esq. of Newcastle.