If one were to ask the physiologist: What do you expect us to find in our anatomical investigations on the nerve-endings in the submaxillary gland, he would undoubtedly answer: “You will find an arrangement analogous, if not similar, to that in the striped muscle; the nerve-fibre will be seen to approach the alveolus, penetrate its covering, and the protoplasm of the nerve and the gland-cell will be found to come in contact, if not to coalesce.” And that is what has been found by Pflüger. It has been my endeavor for some time to find something similar to the descriptions of Pflüger, but so far in vain, although many an alveolus has been carefully examined, flattened out and slowly crushed, so that each nucleus could be diagnosed, but never have I found anything which would remind me of the drawings by Pflüger in Stricker’s ‘Histological Handbook.’ In this matter I reasoned thus: If there are any such structures as specialized nerve-endings present in the glandular elements, we might look for an analogy either to the striped muscle fibres or to the capillaries, in both of which nerve-endings are known to be present. In the former case we have the so-called end-plate—the nerve fibre ends in a multi-nucleated mass—but as the muscle fibre, standing for a number of cells, is so different a structure from the gland-cells, we might, with greater probability, expect some such arrangement as we see on the capillaries. Here we see fine fibrils, provided with nuclei, exceeding the fibres two to four times in thickness, entwining the capillary, thus coming in contact with each of the cells composing the capillary wall. In the (submaxillary) gland there are similar structures to be influenced; at least in the capillary as well as in the gland, we have cells lying side by side to be influenced by nerves—hence we might expect similar structures. Although the books in general have very little to say about the nerve supply of the capillaries, yet it is a fact, and can well be demonstrated, _e. g._, in the frog’s muscle, that such is the arrangement. As a rule, the fibril cannot so readily be detected, but the nuclei belonging to it are not difficult to recognize. A still more convenient and instructive locality is the base of the frog’s mouth, where everything is one plane, and where the nerve fibres can be followed to their ultimate ramifications.