The specialization of protoplasm to form a cell is perhaps its most remarkable peculiarity. Not only is protoplasm differentiated to form different structures, but it devotes the energy evolved in its ceaseless change to different purposes. The protoplasm of the motor organs of the cell expends itself wholly in producing the physical movements necessary to approach and capture food. When this has been passed into the cell, protoplasm of another variety works to refine and dissolve it, and then passes it on to the nucleus. The protoplasm of the nucleus, again, has different work to do. It devotes its energy to producing chemical changes in the raw material, and converting it into new compounds which the various parts of the cell can assimilate. Some of these it retains for its own needs; the rest it dispenses to the motor and other organs to repair their waste, and supply them with energy to obtain more food. Thus do the different varieties of protoplasm which compose a cell supply one another’s needs, and enable one another to live; and thus does a cycle of chemical changes form the foundation upon which the whole fabric of life rests. But into details we cannot yet go, for our investigations of the material basis of life have not yet carried us beyond these general conclusions. At present we know nothing definite about the first causes of life, and, though we have hopes, perhaps we never shall. Meanwhile we are observing, analyzing, and classifying the phenomena in which life is manifested, in the hope that at last light may break through upon our researches, and we may be able, if not to synthesise protoplasm in a test-tube, at least to demonstrate its workings in equations. In the meantime, our actual knowledge of living matter can still be compressed into the words in which Professor Huxley summed it up years ago: ‘Carbon, hydrogen, oxygen, and nitrogen are all lifeless bodies. Of these, carbon and oxygen unite, in certain proportions and under certain conditions, to give rise to carbonic acid; hydrogen and oxygen produce water; nitrogen and hydrogen give rise to ammonia. These new compounds, like the elementary bodies of which they are composed, are lifeless. But when they are brought together under certain conditions they give rise to the still more complex body, protoplasm, and this protoplasm exhibits the phenomena of life.’ Until we have further knowledge of the changes which constitute these phenomena, physiology must remain descriptive rather than explanatory. ESSAY II. THE CHEMISTRY OF THE BODY. I. The cell is usually very minute—indeed, absolutely invisible without a microscope, though in some cases it is a fair size. The whole yolk of an egg is a single cell until its minute nucleus, a speck on one side, starts dividing and it becomes several. By the time the chick is ready to be hatched there are millions.