It is well-known to those familiar with the classes, that certain appetites or habits, if indulged abnormally and excessively through two or more generations, come to have an almost irresistible force, and, no doubt, modify the brain so as to constitute almost an insane condition. This is especially true of the appetite for liquor and of the sexual passion and sometimes of the peculiar weakness, dependence, and laziness which make confirmed paupers. The writer knows of an instance in an alms-house in Western New York, where four generations of females were paupers and prostitutes. Almost every reader who is familiar with village life will recall poor families which have had dissolute or criminal members beyond the memory of the oldest inhabitant, and who still continue to breed such characters. I have known a child of nine or ten years, given up, apparently beyond control, to licentious habits and desires, and who in all different circumstances seemed to show the same tendencies; her mother had been of similar character, and quite likely her grandmother. The "gemmules," or latent tendencies, or forces, or cells of her immediate ancestors were in her system, and working in her blood, producing irresistible effects on her brain, nerves, and mental emotions, and finally, not being met early enough by other moral, mental, and physical influences, they have modified her organization, until her will is scarcely able to control them and she gives herself up to them. All those who instruct or govern "Houses of Refuge," or "Reform Schools," or Asylums for criminal children and youths, will recall many such instances. They are much better known in the Old World than this; they are far more common here in the country than in the city. My own experience during twenty years has been in this regard singularly hopeful. I have watched great numbers of degraded families in New York, and exceedingly few of them have transmitted new generations of paupers, criminals, or vagrants.